He was ordered by his doctor at Baptist Hospital to rest for at least a week, the 31-year-old reggaeton singer's publicist said in a statement.
"Now I'm going home to rest a while," Daddy Yankee said.
He was hospitalized early Friday.
Daddy Yankee has postponed a promotional tour for his new album, "El Cartel: The Big Boss," released by El Cartel Records/Interscope.
Reggaeton is a mix of reggae, rap and Latin music styles.