The movie's narrator, actor Bill Paxton, and film crew members will also be there.
Festival goers will be invited to don 3-D glasses for the Imax movie, which will be screened May 17 in the Palais des Festivals' main Lumiere Amphitheater.
The film recounts the efforts of a deep-sea research team to uncover the secrets of the long-sunken ocean liner Titanic. Cameron developed a special underwater camera system to capture the 3-D "Ghost" images.
The movie, which opened in the U.S. in April, is being shown in Imax-format auditoriums and specially retrofitted 35mm theaters.