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Oxford coronavirus vaccine trial results "extremely encouraging," U.K. government says

COVID-19 vaccine trial shows promising results
Oxford vaccine prompts protective immune response in human trials 03:29

A senior British official has called the latest news on an Oxford University team's potential coronavirus vaccine "extremely encouraging." The results of the Phase I/II trial of the vaccine being developed by Oxford's Jenner Institute, in conjunction with pharmaceutical giant AstraZeneca, showed that it is safe and "produced strong immune results," according to the research published on Monday in The Lancet medical journal.

The vaccine caused a 2-pronged immune response, a news release from the Jenner Institute at Oxford said. First, within 14 days, it triggered a T cell response, generating white blood cells that can attack infected cells. Second, within 28 days, it provoked an antibody response. Antibodies are able to prevent the virus from infecting cells when it is initially contracted, according to the release.

"Those are two parts of the immune system that ideally work together to protect against viral infections," Professor Sarah Gilbert, who heads up the Oxford team, explained to CBS News' Charlie D'Agata.

A photo provided by the COVID-19 Vaccine Team at the University of Oxford's Vaccine Centre in England shows a researcher working on the manufacture of a potential vaccine for the disease caused by the new coronavirus. Sean Elias/Oxford Vaccine Centre

The U.K. Phase I/II trial began in April and involved more than 1,000 healthy volunteers who were between 18 and 55 years old. Some of those volunteers received a second, booster dose of the vaccine, and they appeared to benefit most.

"We saw the strongest immune response in the 10 participants who received two doses of the vaccine, indicating that this might be a good strategy for vaccination," Professor Andrew Pollard, Chief investigator of the Oxford Vaccine Trial at Oxford University and co-author of the study, said.

Crucially the trial also showed that the candidate vaccine produced no serious side effects, causing only minor headaches, fatigue and some soreness around the point of injection. 

"We're all getting a sigh of relief," CBS News medical contributor Dr. David Agus told D'Agata of the trial results. "We're getting the immune responses that science hoped for.

Coronavirus vaccine trial shows promising results but hurdles remain 02:47

Oxford is working with AstraZeneca to develop, manufacture, and produce a coronavirus vaccine on a large scale. The unprecedented effort aims to make some 2 billion doses of the vaccine available globally, through partnerships with manufacturers in several countries, by early next year. 

Lead scientist Gilbert told the BBC on Tuesday morning that while the hope was still to be able to make millions of doses available by this autumn, there was still "absolutely no certainty" of that timeline, as the final, Phase III trials were still ongoing, and the roll-out of the vaccine on a large scale was also contingent on the manufacturing process and individual nations' safety regulators approving it for emergency use.   

While the latest results are encouraging, they show that the trial vaccine creates the reaction in the body that should give immunity to the disease. The Phase III trials, to prove it actually gives people that immunity in the real world, are already ongoing, involving a far larger sample of people, in the U.K., Brazil, and South Africa. A Phase III human trial of the Oxford vaccine involving some 30,000 people will begin in the United States in August.

Oxford scientists test possible coronavirus vaccine in South Africa 01:43

"While there is more work to be done, today's data increases our confidence that the vaccine will work and allows us to continue our plans to manufacture the vaccine at scale for broad and equitable access around the world," Mene Pangalos, Executive Vice President of BioPharmaceuticals Research and Development at AstraZeneca, said.

The U.S. government has invested a whopping $1 billion in Oxford's trial vaccine already, gambling on it being a success to secure millions of doses as soon as possible. 

Britain has also poured about $90 million into the work by Oxford's Jenner Institute for vaccine research. On Monday, British government Business Secretary Alok Sharma called the latest trial results "extremely encouraging, taking us one step closer to finding a successful vaccine to protect millions in the U.K. and across the world."  

The Oxford vaccine has been out in front of about 15 serious global competitors for months, but a few others are hot on the team's heels.

Moderna advances potential coronavirus vaccine as U.S. cases surge 03:48

Just last week, officials announced similarly hopeful results from Phase I trialing of a vaccine being developed by the National Institutes of Health and Moderna Inc. The experimental vaccine will move to its most important step around the end of July: A 30,000-person study to prove the shots are effective at stopping coronavirus infection.

The U.K. vaccine news was published Monday in The Lancet along with another study on a Chinese vaccine trial. That vaccine also showed promise, creating a strong antibody and T cell response in more than 90 percent of those given the injection after 28 days.

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