Clinton's ad "Level" focuses on the issue that voters have said is the most pressing issue of the campaign, the economy, and says its time to "level the playing field against the special interest."
The ad is aimed at blue-collar and middle class voters that Clinton and Obama are both courting heavily.
"Standing up for people who weren't getting a fair shake, that's been the purpose of my life," Clinton says in the ad. "And it will be the purpose of my presidency."
Clinton also ran the "Level" ad in Texas and Mississippi, featuring the same message but using different shots of local voters.