1986 First diagnosis of bovine spongiform encephalopathy (BSE), a new disease in cattle, is made.
1988 Britain makes BSE a notifiable disease.
July 7, 1988 Britain announces that all cows known to be infected with BSE will be destroyed as a precautionary measure.
1989 Britain bans human consumption of certain offal, including brain, spinal cord, thymus, spleen and tonsils.
1990 European Commission bans imports to the continent from Britain of cattle over six months old.
Sept. 25, 1990 Ban is imposed on use of offal from cattle in animal feed.
1994 European Union approves proposal to ban exports of meat containing bones from herds which had not been free of BSE for six years instead of two.
Dec. 7, 1994 European Union agrees to ease export curbs on beef from British cattle born since January 1, 1992.
1996 British government admits for the first time that BSE could be transmitted to humans in the new form of Creutzfeldt Jakob disease (vCJD).
March 23, 1996 Fast food giant McDonald's suspends the sale of British beef products in its restaurants in Britain.
March 27, 1996 European Union ban on British beef and beef products is announced.
April 1, 1996 Britain offers a range of actions including general and targeted culling of cows. It would involve killing all unproductive cows over the age of 30 months and destroying their carcasses.
April 24, 1996 Britain offers to slaughter up to 40,000 cows in a bid to speed up elimination of mad cow disease. This offer is increased to 80,000 later.
May 21, 1996 Prime Minister John Major says Britain will no longer cooperate in E.U. business until the ban on its beef exports had been eased and a framework for a complete lifting put in place.
May 24, 1996 Britain issues proceedings in the European Court of Justice seeking the annulment of the beef ban.
June 11, 1996 European Commission formally lifts export ban on British beef by-products.
June 19, 1996 Framework deal for gradual lifting of ban includes Britain agreeing to cull up to 67,000 more older cattle.
June 21, 1996 Deal agreed on lifting beef ban at Florence summit of E.U. leaders.
July 12, 1996 The European Court of Justice rejects a bid by Britain for an immediate suspension of the European Union's worldwide ban on British beef exports.
July 22, 1996 E.U. scientists say BSE can infect sheep.
Aug. 1, 1996 Britain's agriculture ministry confirmed that mad cow disease can be passed from cow to calf.
Aug. 2, 1996 A British scientist said that reports that cows can pass BSE on to their calves meant it was possible pregnant omen with vCJD could infect their babies.
Aug. 19, 1996 A British coroner ruled that Peter Hall, a 20-year-old vegetarian who died of the vCJD, caught it from eating beefburgers as a child. The verdict is the first to legally link a human death to mad cow disease.
1997 The European Parliament condemned European Commission President Jacques Santer and Britain for serious errors in the way they handled the mad cow crisis.
Dec. 3, 1997 Britain banned the sale of boneless beef as a precautionary move to stop the risk of mad cow disease.
March 16, 1997 E.U. farm ministers voted to ease the worldwide ban on British beef exports and allow a limited resumption in exports from Northern Ireland of beef from cattle in herds guaranteed to be free of mad cow disease for eight years.
Aug. 1, 1999 An export ban on British beef following the mad cow disease scandal was lifted after 3½ years.
Sept. 22, 1999 The British government's chief medical adviser warned that the country could face a possible epidemic of human mad cow disease in the years ahead.
Oct. 29, 1999 The European Commission's top scientists gave British beef a clean bill of health.
June 29, 2000 British Agriculture Minister Nick Brown announces that a cow, born after measures were introduced to eradicate mad cow disease, had been found to have BSE.
Oct. 2, 2000 An independent British inquiry's 16-volume report into "mad cow's disease" and its human form is given to Health Secretary Alan Milburn and Agriculture Secretary Nick Brown.
Oct. 26, 2000 Britain's official report into BSE criticizes officials for consistently playing down the risk to humans and failing to properly coordinate a government response. British government announces compensation scheme for the victims of the human form of mad cow disease.
Nov. 7, 2000 French farmers decide to no longer sell meat from cows born before mid-1996, the date when France introduced strict measures to fight the illness.
Nov. 8, 2000 French Prime Minister Lionel Jospin tries to soothe spiraling fears about the safety of beef, urging calm and criticizing farmers for fueling general panic about deadly mad cow disease.
Nov. 10, 2000 France bans sweetbreads, the Swiss Red Cross limits blood donations from people who spent time in Britain, and the European Union's health and consumer protection commissioner urged EU member nations to go beyond a recent requirement that they randomly test their herds by January.
Nov. 14, 2000 France bans the T-Bone steak and the use of animal feed made with meat, calls for a review of slaughterhouse practices and triples funds for studying the cause of BSE.
Nov. 17, 2000 Italy bans most beef imports from France, hoping to prevent mad cow disease from speading in the country.
Nov. 18, 2000 Greek butchers associations begin a boycott of French beef in a bid to stop a sharp decline in sales in the country, saying they would only sell Greek beef and pledging to set up blockades to stop the distribution of French imports.
Nov. 21, 2000 European Union farm ministers order cattle over 30 months old deemed to be at higher risk from the brain-wasting disease to be tested for BSE as of Jan. 1, with all cattle categories over 30 months old to be tested as of July 1.
Nov. 22, 2000 Spain confirms its first case of mad cow disease and investigates a second possible case. Farms where the cows lived are quarantined.
Nov. 24, 2000 German Chancellor Gerhard Schroeder promises to get tough in fighting mad cow disease after two German cows test positive for BSE. Portugal's Azores Islands report the first case of mad cow disease there, involving an animal imported two years earlier from Germany.
Dec. 4, 2000 At a special meeting, EU agriculture ministers approve a six-month ban on the use of animal products in animal feed. Germany expresses concern that the ban is too short. The EU estimates the cost of a six-month ban at $1.3 billion.
Dec. 7, 2000 Germany, arguing that a six-month ban is too short, pushes European Union leaders to agree to make the six-month-ban on the use of animal products in fodder permanent. Germany's Chancellor Gerhard Schroeder announces a permanent ban has been ordered.
Dec. 8, 2000 EU ministers end up supporting a six-month rather than a permanent ban on animal products in animal feed. The ministers agree to set up a food regulatory agency. They also agree to keep out of the food chain all cattle older than 30 months that have not been tested for the disease.
Dec. 19, 2000 The French government announces it is banning blood donations of people who spent more than a year in Britain from 1980 to 1996, a precautionary measure against mad cow disease. German officials rush to reassure consumers that their sausages are safe after a European Union official hinted the country's beloved bratwurst, currywurst or even weisswurst could also be considered suspect in the mad cow disease scare.
Dec. 20, 2000 Germany's health minister warns the public to stop eating some sausages made of meat from the backbones of cattle and calls on producers to take the products off the market, saying it was a precaution based on the recommendation of scientists.
Jan. 2, 2001 France begins testing cattle aged 30 months and older, six months before such testing mandated by the European Union was required to begin. Spanish authorities announce two new cases of mad cow disease.
Jan. 5, 2001 Hoping to fend off criticism of its reaction to the panic, the German government proposes lowering the age of cows to be tested for BE, implementing tougher food safety inspections and banning animal-based feeds and risky products. Spain reports three new cases of mad cow, while Australia and New Zealand announce they will ban all beef imports from Europe.
Jan. 9, 2001 Germany's agriculture and health ministers resign over their handling of the mad cow scare. The Belgian Federal Agency for Food Safety reports 161 cases of BSE in 2000, more than five times the number detected in 1999. French farmers block a slaughterhouse to protest the economic impact of the disease.
Jan. 16, 2001 The European Union appeals to consumers to stay calm, despite the discovery of suspected mad cow cases in Austria, Spain, Bavaria, Belgium, and in an Italian slaughterhouse that has supplied beef for McDonald's hamburgers. Some of the suspected cases were in areas previously believed to be in the clear. The EU says it's only natural that new cases would be discovered, now that a mandatory beef testing policy is in place.
Jan. 18, 2001 An FDA advisory panel votes to ban blood donations from anyone who lived in France, Ireland or Portugal for 10 or more years after 1980. A wider ban had been requested by the American Red Cross.
Jan. 25, 2001 The U.S. Food and Drug Administration quarantines some cattle in Texas to investigate whether the animals ate feed made from carcasses of cows. Regulations meant to keep mad cow disease out of the United States prohibit that practice.
Jan. 26, 2001 The U.N. Food and Agriculture Organization urged precautions worldwide against mad cow disease, saying that any country that imported cattle, meat or bone meal from Western Europe since the 1980s was at risk. Germany, meanwhile, dropped the testing age for cattle from 30 months to 24 months.
Jan. 31, 2001 Germany said it would destroy about 400,000 cattle that may be infected with the disease. Spanish officials said they had detected three new cases of the disease, bringing to 12 the number discovered there so far.
Feb. 16, 2001 France asks for aid for farmers affected by the mad cow scare, Germany passes a law increasing government's powers to deal with the beef emergency and Italy confirms its second case of BSE.