Cholesterol Drugs May Treat Psoriasis

Once again, cholesterol -lowering statin
drugs have been shown to be good for more than the heart.

Already linked to a reduced risk of rheumatoid arthritis , diabetes, multiple
sclerosis, and cancer, statins also may help to improve symptoms of psoriasis ,
researchers report.

In a study of 232 people taking medication for psoriasis , those who also
took statins had fewer of the thick, red, scaly, itchy patches that are the
hallmark sign of psoriasis, compared with people who didn't take the
cholesterol-lowering drugs.

"There was a trend toward less severe psoriasis severity in people taking
statins," says researcher Adam Perry, a fourth-year medical student at Emory
University in Atlanta.

The study is preliminary and doesn't prove cause and effect. And no one
should start taking statins in an attempt to ward off psoriasis symptoms,
doctors stress.

But the findings, presented at the American Academy of Dermatology annual
meeting, raise an interesting possibility worthy of further study, experts
agree.

Statins Reduce Inflammation

About 7.5 million Americans suffer from psoriasis, a lifelong (chronic)
disorder characterized by inflammation of skin and, often, the joints.

Statins have been shown to reduce inflammation in the body in animal and lab
studies.

To date, there has only been one small study of seven patients looking at
the link between statins and psoriasis, Perry says. In that study, there was
about a 50% reduction in symptom severity after eight weeks of statin
therapy.

The new study involved 232 people with psoriasis, 66 of whom were taking
statins for high cholesterol .

After starting a new medication for their psoriasis, there was a 64%
reduction in the percentage of the body covered with the psoriasis lesions in
people on statins. In contrast, there was only a 45% reduction in people not
taking statins.

Statistical analysis showed the finding could have been due to chance. But
Perry and experts like Alan Menter, MD, who was not involved with the study,
agree that's probably because too few people were studied.

"There's a general air of excitement about the possibility [that statins
could improve psoriasis symptoms]. Given that statins fight the inflammation
[that fuels psoriasis], we would like to follow up," says Menter, chair of the
psoriasis research unit at Baylor Research Institute in Dallas.

Since people in the study were taking medications for psoriasis , it's very
difficult to tease out the statins' role in improving symptoms, he adds.

What is needed, Menter tells WebMD, is a study of patients not taking
psoriasis medications, half of whom are prescribed statins for high cholesterol
and half of whom have normal cholesterol and thus are not taking statins. Then
the people will be followed over time to see if symptoms improve more in the
group taking statins.

The International Psoriasis Council, of which Menter is a member, is
considering such a study, he says.

Robert Kalb, MD, clinical professor of dermatology at the State University
of New York, Buffalo, tells WebMD that many people with psoriasis also have
high cholesterol or other risk factors for heart disease and stroke that may
require statin therapy.

"So it certainly makes sense to use statins in these patients," he says.
"But at this point, I wouldn't put a psoriasis patient on statins to improve
symptoms."

"If it turns out that statins lower psoriasis risk, that will be great for
patients. We can put them on one drug not only to help improve psoriasis
symptoms but also to reduce their risk of cardiovascular disease," Kerry
says.

The researchers didn't find out whether the dose or type of statin drug
affected the results.

Statin drugs include Lipitor, Zocor, Crestor, Pravachol , Mevacor , and
Lescol.

By Charlene Laino
Reviewed by Louise Chang
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