Last Updated 10:47 PM ET
(CBS/AP) ISLAMABAD - Pakistan's "Day of Love for the Prophet" turned into a deadly day of gunfire, tear gas and arson.
Thousands angered by an anti-Muslim film ignored pleas for peaceful rallies and rampaged in several Pakistani cities Friday in battles with police that killed 19 people and touched off criticism of a government decision to declare a national holiday to proclaim devotion for the Prophet Muhammad.
The film, which was produced in the United States and denigrates the prophet, has outraged many in the Muslim world in the 10 days since it attracted attention on the Internet, and there were new, mostly peaceful protest marches in a half-dozen countries from Asia to the Middle East.
But it is Pakistan that has seen the most sustained violence, driven by a deep well of anti-American sentiment and a strong cadre of hard-line Islamists who benefit from stoking anger at the U.S. At 49 people -- including the U.S. ambassador to Libya -- have died in violence linked to the film around the world.
Analysts accused the Pakistani government of pandering to these extremists by declaring Friday to be an official holiday -- calling it a "Day of Love for the Prophet." Officials urged peaceful protests, but critics said the move helped unleash the worst violence yet caused by the film, titled "Innocence of Muslims."
In addition to those killed, nearly 200 others were injured as mobs threw stones and set fire to cars and movie theaters, and battled with police who responded with tear gas and gunfire.
"The people were just waiting for a trigger," said Imtiaz Gul, director of the Islamabad-based Center for Research and Security Studies.
In an attempt to tamp down the anger, the U.S. Embassy in Islamabad purchased spots on Pakistani TV on Thursday that featured denunciations of the video by President Barack Obama and Secretary of State Hillary Rodham Clinton. But their comments, which were subtitled in Urdu, the main Pakistani language, apparently did little to moderate the outrage that filled the country's streets.
Police fired tear gas and live ammunition to push back the tens of thousands of protesters they faced in Pakistan's capital, Islamabad, and the major cities of Lahore, Karachi and Peshawar. They were successful in preventing the protesters from reaching U.S. diplomatic offices in the cities, even though the demonstrators streamed over shipping containers set up on major roads to block their path.
The demonstrators, who were led by hard-line Islamist groups, hurled rocks at the police and set fire to their vehicles. They also ransacked and burned banks, shops, cinemas and Western fast-food restaurants such as KFC and Pizza Hut.
Clinton thanked the Pakistani government for protecting the U.S. missions in the country and lamented the deaths in the protests.
"The violence we have seen cannot be tolerated," she said, speaking alongside Pakistani Foreign Minister Hina Rabbani Khar in Washington. "There is no justification for violence."
Khar thanked Obama and Clinton for speaking out against the video, saying it sent "a strong message, and that message should go a long way to ending the violence on many streets on the world."
The deadliest violence occurred in the southern port city of Karachi, where 14 people were killed, said hospital officials. More than 80 people were injured, said the top government official in the city, Roshan Ali Shaikh. At least three of the dead were policemen, one who died when hundreds of protesters attacked a police station.
"We are all ready to die for Prophet Muhammad," said Karachi protester Mohammad Arshad. "We want to show the world that Muslims are one and united on the issue."
Five people were killed and 60 wounded in the northwestern city of Peshawar, said police official Bashir Khan.
One of the dead was identified as Mohammad Amir, a driver for a Pakistani TV station who was killed when police fired at protesters torching a cinema and hit his vehicle, said Kashif Mahmood, a reporter for ARY TV who also was in the car. The TV channel showed doctors at a hospital trying unsuccessfully to save Amir's life.
At least 45 people, including 28 protesters and 17 policemen were wounded in clashes in Islamabad, where police fought with more than 10,000 demonstrators in front of a five-star hotel near the diplomatic enclave where the U.S. Embassy and other foreign missions are located. A military helicopter buzzed overhead as the sound of tear gas being fired echoed across the city.
In northwestern Pakistan, demonstrators burned the Sarhadi Lutheran Church in the city of Mardan, but no one was injured, said senior police officer Salim Khan
The government temporarily blocked cellphone service in 15 major cities to prevent militants from using phones to detonate bombs during the protests, said an Interior Ministry official, speaking on condition of anonymity because he was not authorized to talk to the media. Blocking cellphones also had the benefit of making it harder for people to organize protests.
Pakistani Prime Minister Raja Pervaiz Ashraf urged the international community to pass laws to prevent people from insulting the prophet, and the Foreign Ministry summoned the U.S. charge d'affaires in Islamabad, Richard Hoagland, over the film.
"If denying the Holocaust is a crime, then is it not fair and legitimate for a Muslim to demand that denigrating and demeaning Islam's holiest personality is no less than a crime?" Ashraf said in a speech to religious scholars and international diplomats in Islamabad.
Denying the Holocaust is a crime in Germany, but not in the U.S.