"CSI: Crime Scene Investigation," "Grey's Anatomy" and "House" are nominated for favorite TV drama and "Two and a Half Men," "Ugly Betty" and "Samantha Who?" are nominated for favorite TV comedy.
Queen Latifah will host the viewer-voted awards show, to air live Jan. 7 from the Shrine Auditorium in Los Angeles. Awards will be presented in over 40 categories, including favorite new TV drama, talk-show host, rock song, on-screen matchup and leading lady.
New categories include favorite superhero, TV drama diva and movie cast.
Nominees also include Christian Bale, Brad Pitt and Mark Wahlberg for favorite leading man; Anne Hathaway, Kate Hudson and Queen Latifah for favorite leading lady; Steve Carell, Jim Carrey and Adam Sandler for favorite funny male star; and Ellen DeGeneres, Tina Fey and Whoopi Goldberg for favorite funny female star.