Updated 10:04 p.m. ET
MOBILE, Ala. Twisters hopscotched across the Deep South, and, along with brutal, straight-line winds, knocked down countless trees, blew the roofs off homes and left many Christmas celebrations in the dark. Holiday travelers in the nation's much colder midsection battled treacherous driving conditions from freezing rain and blizzard conditions from the same fast-moving storms.
As predicted, conditions were volatile throughout the day and into the night with tornado warnings still out for some parts of Alabama. The storms were blamed for two deaths, several injuries, and left homes from Louisiana to Alabama damaged.
In Mobile, Ala., a tornado or high winds damaged homes, a high school and church, and knocked down power lines and large tree limbs in an area just west of downtown around nightfall. WALA-TV's tower camera captured the image of a large funnel cloud headed toward downtown.
Rick Cauley, his wife, Ashley, and two children were hosting members of both of their families. When the sirens went off, the family headed down block to take shelter at the athletic field house at Mobile's Murphy High School.
"As luck would have it, that's where the tornado hit," Cauley said. "The pressure dropped and the ears started popping and it got crazy for a second." They were all fine, though the school was damaged. Hours after the storm hit, officials reported no serious injuries in the southwestern Alabama city.
Meanwhile, blizzard conditions hit the nation's midsection.
"Certainly those roads are slick. If you don't have to get out, please don't get out," Transportation Official Mark Shelton warned holiday travelers, according to Miller.
CBS News correspondent Michelle Miller reports that the bulk of the storms will be hitting the Northeast by Wednesday night.
Earlier in the day, winds toppled a tree onto a pickup truck in the Houston area, killing the driver. Icy roads already were blamed for a 21-vehicle pileup in Oklahoma, and the Highway Patrol there says a 28-year-old woman was killed in a crash on a snowy U.S. Highway near Fairview.
The snowstorm that caused numerous accidents pushed out of Oklahoma late Tuesday, carrying with it blizzard warnings for parts of northeast Arkansas, where 10 inches of snow was forecast. Freezing rain clung to trees and utility lines in Arkansas and winds gusts up to 30 mph whipped them around, causing about 71,000 customers to lose electricity for a time.
Blizzard conditions were possible for parts of Illinois, Indiana and western Kentucky with predictions of 4 to 7 inches of snow.
An apparent tornado also caused damage in Grove Hill, about 80 miles north of Mobile.
Mary Cartright said she was working at the Fast Track convenience store in the town on Christmas evening when the wind started howling and the lights flickered, knocking out the store's computerized cash registers.
"Our cash registers are down so our doors are closed," said Cartright in a phone interview.