History's first Latin American pope travels to Mexico on Friday for a weeklong tour of some of the most violent, poverty-stricken and peripheral places in the Americas.
He'll be bringing a message of hope and solidarity to victims of drug violence, trafficking and discrimination -- a message the Vatican hopes will also resonate north of the border.
Nearly four decades after St. John Paul II began his globe-trotting papacy in Mexico, Francis too will begin his trip by praying before the Virgin of Guadalupe shrine. But after that, he will be entering into uncharted papal territory.
Click ahead to see the five things to know about Francis' trip to the largest Spanish-speaking Catholic country in the world.