"Desperate Housewives" stars Vanessa Williams, Felicity Huffman, Eva Longoria, Teri Hatcher and Marcia Cross are moving on from Wisteria Lane. The ABC series ran for eight seasons.
Hugh Laurie played Dr. Gregory House on Fox's medical drama "House" for eight seasons. The show's series finale airs on May 21, 2012.
The CW has axed Sarah Michelle Gellar's mystery drama "Ringer" after one season. Here, Gellar, left, and fellow cast member Ioan Gruffudd, promote the show at the CW Showtime summer press tour in Beverly Hills, Calif., on Aug. 4, 2011.
Ashley Judd played a former CIA agent searching for her kidnapped son on the drama "Missing," which was cancelled by ABC following its first (and only) season.
"CSI: Miami" actor David Caruso, seen here celebrating the 200th episode of of the television show on Oct. 15, 2010, in Manhattan Beach, Calif., is out of a job after 10 seasons of playing Horatio Caine. CBS execs said they chose to cancel "CSI: Miami" over fellow spin-off "CSI: NY" because the network needed the Sunday night time slot.
Chelsea Handler played the sister on "Are You There, Chelsea?", which was cancelled by NBC after one season. Based on Handler's best-selling book, "Are You There Vodka? It's Me, Chelsea," the comedy also starred Laura Prepon, Jake McDorman, Lauren Lapkus, Lenny Clarke, Ali Wong and Mark Povinelli.
ABC cancelled the Dallas-set Sunday drama "GCB," after just one season. It starred actresses Kristin Chenoweth, seen here, with an ensemble cast that included Leslie Bibb and Annie Potts.
Actor Jason Isaacs played a police detective who finds himself living two parallel lives on the NBC drama "Awake." Introduced as a mid-season replacement in January 2012, it was history in May.
Christina Ricci played a stewardess on ABC's '60s-set "Pan Am." ABC grounded the jet-setting series after one season.
The cancellation of "Harry's Law," a Cincinnati-based legal drama starring actress Kathy Bates (seen here), was controversial. One of the network's highest-rated scripted series, it had too many older-than-50 viewers to be viable, NBC execs said.
From left, actresses Kristi Lauren, Katie Finneran and Jamie Pressly speak onstage at the "I Hate My Teenage Daughter" panel during the FOX portion of the 2011 Summer TCA Tour on Aug. 5, 2011, in Beverly Hills, Calif. The network cancelled the sitcom after one season.
Poppy Montgomery played a detective with a perfect memory on the CBS crime drama "Unforgettable." The Tuesday night show, which also starred Dylan Walsh, was cancelled after just one season.
From left, actors Jason Butler Harner, Sarah Jones, Jorge Garcia and Sam Neill attend the 2011 Fox Upfront on May 16, 2011, in New York, where the network announced that their J.J. Abrams-produced show "Alcatraz" would start in January 2012. It was cancelled after one season.
Patrick Wilson, star of "A Gifted Man," is not sad that CBS cancelled his drama, about a surgeon visited by the ghost of his deceased wife, after just one season. The actor reportedly tweeted about the cancellation, writing "I couldn't be happier. As good as it was (sometimes) it was not what I signed on for."
Rob Schneider's comedy "Rob," about a solitary man who marries into a huge Mexican-American family, arrived in January as a mid-season replacement and was cancelled in May. Schneider was the creator as well as the star of the CBS sitcom.
Actor Bruce Greenwood is one of the stars of "The River," the scfi-fi horror series that ABC introduced in February. It was cancelled after just eight episodes.
CBS cancelled its rookie cop drama "NYC 22" after just one season. The series' cast included actress Leelee Sobieski (seen here at an event on May 1, 2012).
Fox cancelled its half-hour sitcom "Breaking In," which starred Christian Slater (pictured), Michael Rosenbaum and Odette Annable, after two seasons.
From left, actors Jeffrey Tambor, Amanda Peet and David Walton of the NBC sitcom "Bent" attend the 2011 NBC Upfront at The Hilton Hotel on May 16, 2011, in New York. The network cancelled the series after one season.
After a nine-year run, "One Tree Hill" has come to an end. The series finale aired on April 4, 2012.