And to some astonishment, the people standing in line to get in are not all the usual suspects, reports CBS News correspondent Nancy Cordes.
Cathy Plume knows she and her friends aren't exactly the target audience for "Twilight."
"We laugh about how silly it is to be captured by this movie," said Plume, who is not exactly a high school student.
The movie is about teenagers and aimed at teenagers. Yet the theaters are filled with 40-somethings like Meg Symington.
"Everybody remembers their high school love, their first crush, the emotion of it all," Symington said. "I think even at our age we can relate to that."
"New Moon" Sucks Up $140.7M in 1st Weekend
"New Moon" Sets Midnight Screening Record
Letterman to Robert Pattinson: "Bite Me"
Photos: Big Smiles at "New Moon" Premiere
Photos: "New Moon" Premiere
Photos: "New Moon" in Europe
Over the Moon for "New Moon"
Fan Frenzy At 'New Moon' Premiere
Vampires in the Movies
Of course, most high school crushes don't involve werewolves or vampires. Twilight's love triangle features both.
Team Edward, he represents the vampires, so if you like bloodsucking, you're on team Edward," explained moviegoer Karl Felix-Hawver. "Then there's team Jacob; he's a werewolf."
The movie's blockbuster opening weekend has taken Hollywood by surprise. The Twilight films are based on a series of best-selling novels, but the new movie grossed more than twice what the first film did during its opening weekend.
New Moon's success started even before dawn Friday. It broke a box office record for midnight showings with $26 million in sales. And then it broke "The Dark Knight's" opening day record, earning $72 million.
Some of that was repeat business.
"I've seen it twice. This will be my third time," said one teenage fan waiting in line.
Rabid teenage fans have turned the lead actors into mega-stars. Eighty percent of the audience has been female. Half are under 21. But that means half are past their teenage years. Sarah Solomon brought her mom Amy - though it didn't take much arm-twisting.
"We both sort of wanted to see it, actually," Sarah said.
Mother Amy added, "My sister just saw it last night and called us and said, 'You gotta go, you gotta go!'"
After fans have their fill of this movie, they'll have to wait awhile for the next chapter in the saga. The third movie opens in June.