Tigers spokesman Brian Britten said the Tigers learned of Harwell's death from his agent.
Harwell, who called Detroit Tigers games for four-plus decades and was acquired by the Brooklyn Dodgers for a catcher, announced in September that he had been diagnosed with inoperable cancer of the bile duct. Then 91, he took the news with characteristic poise, saying he planned to continue working on a book and other projects.
"Whatever happens, I'm ready to face it," Harwell told The Associated Press on Sept. 4, 2009. "I have a great faith in God and Jesus."
Shortly after Harwell's announcement, the Tigers honored him during the third inning of a game against Kansas City, showing a video tribute and giving him a chance to address the crowd at Comerica Park.
"In my almost 92 years on this Earth, the good Lord has blessed me with a great journey," Harwell said at a microphone behind home plate. "The blessed part of that journey is that it's going to end here in the great state of Michigan."
Harwell died Tuesday at his home in Novi, about 30 miles northwest of Detroit, according to the Detroit Free Press. The Tigers did not have additional details about his death.
Harwell spent 42 of his 55 years in broadcasting with the Tigers. He was their play-by-play radio voice from 1960-1991 and 1993-2002.
The team and its flagship radio station, WJR, allowed his contract to expire after the 1991 season in what became a public relations nightmare. Then-Tigers president Bo Schembechler, the former Michigan football coach, took the blame. WJR general manager Jim Long later took responsibility for the unpopular move.
When Mike Ilitch bought the franchise from Tom Monaghan, he put Harwell back in the booth in 1993. Harwell chose to retire after the 2002 season.
His big break came in unorthodox fashion.
Brooklyn Dodgers radio broadcaster Red Barber fell ill in 1948, and general manager Branch Rickey needed a replacement. After learning the Crackers needed a catcher, Rickey sent minor league catcher Cliff Dapper to Atlanta and Harwell joined the Dodgers.
Harwell said his most memorable game was the 1951 playoff between the Dodgers and New York Giants for the NL pennant, which Bobby Thomson won with a walk-off home run, but few if any people remember his recount of the "Shot Heard 'Round The World?" at the Polo Grounds that day.
Russ Hodges' exclamation on radio of "The Giants win the pennant!" became one of the most famous moments in sports broadcasting history. Harwell, meanwhile, was calling the first major sporting event televised coast-to-coast in the United States. His work that day has been largely forgotten.
"I just said, `It's gone!' and then the pictures took over," he recalled.
By his own count, Harwell called more than 8,300 major league games, starting with the Dodgers and continuing with the Giants and Baltimore Orioles before joining the Tigers. He missed two games outside of the '92 season: one for his brother's funeral in 1968, the other when he was inducted into the National Sportscasters and Sportswriters Association Hall of Fame in 1989.
The Georgia native's easygoing manner and love of baseball endeared him to generations of Tigers fans, enhancing the club's finest moments and making its struggles more bearable.
Even casual fans could tick off Harwell catchphrases: "Looooooong gone!" for a home run; "He stood there like the house by the side of the road and watched that one go by" for a batter taking a called third strike; and "Two for the price of one!" for a double play.
Foul balls into the stands were "Caught by a man from (whatever town in the area that came to his mind)."
"I started that after I got to Detroit in 1961 or '62, and it just happened by accident," Harwell explained. "I said, `A guy from Grosse Pointe caught that foul ball,' then the next ones were caught by a guy from Saginaw or a lady from Lansing."
The Baseball Hall of Fame honored Harwell in 1981 with the Ford C. Frick Award, given annually to a broadcaster for major contributions to baseball.
Harwell tempered his with modesty. "I just want people to remember me as a guy who showed up for work and tried to do a good job," Harwell told the AP weeks before he retired in 2002.
As Detroit struggled late in Harwell's career - the Tigers had losing records in each of his final nine years in the booth - he became a reminder of better times. A life-sized statue of Harwell stands at the entrance to Comerica Park and its press box is called "The Ernie Harwell Media Center."
Survivors include his wife of 68 years, Lulu, and four children.