The Skittles were tainted with the high-powered pain reliever Oxycontin.
The girl was with her grandparents, driving home Monday from Tampa International Airport, when she became lethargic. They took her to a hospital where she was treated and later released.
Authorities say deputies found several pills mixed in with the Skittles, and say the bag had been resealed. Airport police Chief Paul Sireci says officers pulled about 30 bags of Skittles off store shelves as a precaution.
Sireci says it's possible someone gave the candy to the girl, or she picked up a bag from a bench.
A spokesman for Wrigley, which makes Skittles, told WFTS TV in Tampa they were cooperating fully with the ongoing investigation.
This is the second drug-related incident involving Skittles in the past week.
Last Wednesday in Middleburg, Fla., a boy found a bag of cocaine inside a box of Skittles at the front register of a CVS.
Deputies made contact with a supervisor at CVS to find out how the bag was placed in the box. After reviewing security camera footage, authorities were unable to see when it was placed because of the camera angle.
There is no word yet on whether the incidents are related.