The Broadway lights will dim on the musical "Spider-Man: Turn Off the Dark" in January.
A spokesman for the show, Rick Miramontez, tells CBS News it will move to Las Vegas after its last performance on the Great White Way.
"Spider-Man: Turn Off the Dark" features music from rock band U2’s Bono and the band's guitarist, the Edge.
It was Broadway's most expensive show, with a price tag of $75 million.
It became one of its biggest hits after a rocky start, with an opening night delayed six times, <a href="http://www.cbsnews.com/8301-207_162-57598912/spider-man-show-to-go-on-despite-new-actor-injury/">injuries to several actors</a>, a shake-up that led to the firing of Julie Taymor, the show's original director, and critical drubbing.