The Orangeburg County coroner identified the victim as 20-year-old Brandon Robinson.
The university says the victim was shot Friday afternoon at the Hugine Suites. The school says police are looking for four suspects who made it off campus.
University President Thomas Elzey choked back tears as he promised to keep his students safe. He said the student killed was a nice young man.
Campus Police Chief Mernard Clarkson says police don't know what led to the attack. Clarkson says the campus is secure and students are safe.
South Carolina State is a historically black school with about 3,200 students in Orangeburg, about 40 miles south of Columbia.