The two-hour ceremony in Svay Rolum village, 12 miles south of the capital Phnom Penh, ended with two Buddhist monks blessing the pair and villagers showering them with flowers as wedding music played.
Most Cambodians, almost all Buddhists, also subscribe to animism a belief that spirits can inhabit all sorts of living and inanimate objects. Whenever an odd animal makes an appearance, it is cause for the superstitious to celebrate.
"We married these pythons to ask for health and prosperity in our village," said 41-year-old Neth Vy, owner of female python named Chamrouen.
"We were told (by fortunetellers) that the two pythons are husband and wife and they need to live together, and if we don't marry them we will meet bad luck," said Neth Vy, who found the then-tiny python while fishing 16 years ago.
He said since the snake became part of the household, the family's living conditions had steadily improved and no misfortune had befallen them.
The male python, named Kroung Pich, was caught 12 days ago by Hin Mao, a 44-year-old, childless woman who said she regarded it as her son.