Drury apparently sprained his left knee in a collision with Vancouver's Matt Cooke along the boards. He is expected to make a full recovery, the Avalanche said.
Drury, 24, was the NHL Rookie of the Year in 1998-99 and the Avalanche's leading scorer so far this season with five goals and 12 assists.
The team said Deadmarsh, 25, received a concussion when Vancouver defenseman Ed Jovanovski hit him during a fight. Deadmarsh crumpled to the ice and looked groggy as teammates helped him to the dressing room. He did not return to the game.
Deadmarsh had given Colorado a 3-2 lead with his fourth goal of the season just 20 seconds before the fight.
Doctors examined the pair Thursday.
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