ABC said Wednesday that Franco will appear on the soap opera Feb. 25 and Feb. 28.
Franco is co-hosting the Academy Awards ceremony on ABC with actress Anne Hathaway on Feb. 27.
The actor appears occasionally in the soap opera as an oddball artist named Franco. He made his first appearance in that "General Hospital" role in 2009, and returned for an episode June 30 this year.
He appeared in the movie "Eat Pray Love" this summer and is starring in the thriller "127 Hours."