Penn's "Into the Wild," which he adapted from Jon Krakauer's best-seller about a doomed young idealist, won best feature. Moore, a Flint, Mich., native who maintains a home near Traverse City, Mich., won the award for best documentary for "Sicko," in which he takes the pulse of America's health care system and finds it seriously ailing.
Roger Ebert, New York Mayor Michael Bloomberg, Javier Bardem and Mira Nair were among those presented with honorary Gotham Awards for their contributions to independent film.
The best ensemble cast award went to two movies, "Talk to Me" and "Before the Devil Knows You're Dead." Other winners included: breakthrough director, Craig Zobel for "Great World of Sound"; breakthrough actor, Ellen Page for "Juno"; and best film not playing at a theater near you, "Frownland," directed by Ronald Bronstein.