Fans crowded the block around the Isabel Bader Theatre on Sunday night to catch a glimpse of the former "Friends" star, who is also returning to NBC soon with a guest appearance on "30 Rock."
Aniston told AP Entertainment as she arrived that she loved "everything" about the film - "Management" - by first-time writer-director Stephen Belber.
"It's a nice, quiet role. It's beautifully written. The cast was amazing," Aniston said.
Aniston stars with Steve Zahn and Woody Harrelson in the romance, with a tone similar to her 2002 "The Good Girl" and 2006's "Friends with Money."
Zahn plays a hotel manager who becomes smitten with Aniston's character, and Harrelson is her yogurt mogul ex-boyfriend.
"Her name is Sue Clemens, and she's a person who's sort of cut off emotionally from her life," Belber said.
"She sells art, kind of corporate art. And she channels all her emotions into social causes. And so she doesn't have a lot of social life as a result. And because she's so cut off, Steve Zahn's character finds a way in, sort of sparks something there and reawakens something that she has lost."
Belber said he was grateful that Aniston would join a small, independently-financed movie like his.
"It's something that certainly someone of her stature doesn't have to do," he told AP. "But the fact that she wants to exercise that muscle - she has this great dramatic thing going on underneath the comedy. And when she can flock a line, like I think in this movie she does really well, it's a thrill to watch. And she didn't have to do it, but it's pretty cool she does."
"Management" is seeking distributors at the Toronto International Film Festival, which runs through Sept. 14.