The trip is sponsored by The Five Points of Life program, which increases national awareness of the five ways people can share life with others through donation.
The five points represent whole blood, aphaeresis, bone marrow, umbilical cord blood, and organ/tissue donations.
The purpose of this trip is to raise awareness of the importance of blood donations and organ transplants.
Along the way, the group will make stops in local communities and tell their personal stories to groups of residents gathered at blood drives and related events.
The Five Points of Life is a program created to raise awareness of the need for blood and organ donation. They do not raise money -- all the expenses are paid for by sponsors.
Two of the members of this year's team, Terry Dennis and Perry McGriff, talk to The Saturday Early Show about what they hope to achieve during their 53-day trip.
Dennis's son Matt received a life-saving heart transplant at the age of 3. Now, he's a happy, healthy 20-year-old college student.
McGriff is the founder of the cross-country trip. He says, "Saving one life makes the ride a success."