Publisher Henry Holt and Co. says it will release the 46-year-old actor's memoir in May 2011.
Rob Lowe Leaving 'Brothers & Sisters'
The actor is handling the writing duties on "Stories I Only Tell My Friends," which details his experiences as an actor and father.
Holt president Stephen Rubin described Lowe's book as "a mid-career meditation on his four decades as an actor."
Lowe became a teen heartthrob in 1983's "The Outsiders" and has amassed more than three dozen film credits since then.
He is a star of the ABC drama "Brothers & Sisters" and recently appeared on the NBC sitcom "Parks and Recreation."