The statement said one side of the coins were inscribed with hybrid Greek-Egyptian god Amun-Zeus, while the other side showed an eagle and the words Ptolemy and king in Greek.
Founded by one of Alexander the Great's generals, the Ptolemaic Dynasty ruled Egypt for some 300 years, fusing Greek and ancient Egyptian cultures.
The coins were found north of Qarun lake in Fayoum Oasis 50 miles (80 kilometers) southwest of Cairo.
Other artifacts were unearthed in the area included three necklaces made of ostrich egg shell dated back to the 4th millennium B.C. and a pot of kohl eyeliner from the Ottoman Empire.
The objects will all be displayed in the new Egyptian museum under construction near the pyramids of Giza.