Deputy Mining Minister Jorge Espinosa identified the two known dead as Walter Vera and Paul Aguirre. He said searchers still held hopes they could rescue the two missing miners, Pedro Mendoza and Angel Vera.
Four Miners Trapped in Ecuador
"We hope to find the two other miners alive because they were in a spot that probably was not affected" by the cave-in, Espinosa told The Associated Press.
Juan Cando, president of the Sadco Mine, said searchers were trying to clear away fallen rocks to get to the area where the missing miners were thought to be working, according to a government statement.
The accident happened early Friday in the fifth level of a gold mine near the town of Portovelo, about 250 miles southwest of the capital, Quito.