Westbrook made all four of his 3-point attempts to help the Thunder shoot a season best 13 of 21 on 3-pointers. Kevin Durant scored 21 points and Jeff Green added 20.
Paul Millsap led Utah with 34 points and 10 rebounds and Al Jefferson contributed 21 for the Jazz, who lost their 10th game at home this season.
Durant converted a three-point play to open the fourth quarter give the Thunder a 95-81 lead.
Millsap, who had his fourth 30-plus scoring performance this season, countered with six straight points for the Jazz.
But Durant came right back to spark a 7-0 run with a 3-pointer and capped it with two free throws to give Oklahoma City a 102-87 lead with 8:27 to play. The Jazz only got within single digits once the rest of the way.
Hampered by slow starts all season, the Jazz began the game by making their first 11 shots. Utah is the first NBA team to start a game 11 for 11 since Detroit did it against Milwaukee on Feb. 19, 2010.
But the Thunder, behind James Harden and Eric Maynor, worked their way back into the game when Durant and Westbrook were on the bench.
A night after they beat Phoenix 111-107, the Thunder played fast after Utah's initial burst. Oklahoma City is now 6-3 on the second night of back-to-back sets.
Deron Williams had 14 points and 11 assists in his second game back after missing four games with a strained tendon in his right wrist. But Williams and the Jazz looked winded in the second half as the Thunder blew past them.
Raja Bell also scored 14 for Utah, which has gone 3-9 in the last three weeks. The Jazz attempted 18 3-point shots and made just three.
The Thunder's long-range marksmanship may have caught the Jazz by surprise as they tried to crowd the lane to stop the drives of Westbrook and Durant. The Thunder have the second-lowest 3-point percentage in the league at 32.8 and the last time the Thunder made more than half their 3-point shots was on New Year's Eve with 10 of 18 in a 103-94 win over Atlanta.
Notes: Andrei Kirilenko missed his third straight game with a sprained left ankle and Mehmet Okur sat out with a strained lower back. ... Nick Collison received six stitches after trying to take a charge midway through the second quarter. ... The last time the Jazz made 11 field goal attempts to start a game was March 11, 1998 when they hit their first 12 against Sacramento.