In an interview with Britain's Sky News, Asma al Assad envisioned her husband, Bashar, and Barack Obama joining forces.
"The fact is President Obama is young," al Assad said, "and President Assad is also very young as well, so maybe it is time for these young leaders to make a difference in the world."
Asma was born in London and moved to Damascus after marrying Bashar al Assad nine years ago.
Last week, the Obama administration announced it was sending an ambassador to Syria for the first time in four years.
Click here to read the full Sky News interview.