One hundred thousand fans were treated to a free concert by the nine-time Grammy winner Saturday night. Crowe is helping to raise awareness and funds for the Stand Up 2 Cancer cause, which this year has raised $73 million in grants for cancer research.
The fight against cancer is ongoing, despite the recession, Crow said on "The Early Show" Tuesday.
"At a time when the economy is really suffering and the research dollars just aren't there, this is where it really makes a huge difference. And what Stand Up 2 Cancer is doing is really innovative -- by creating dream teams with research doctors across the world."
Major League Baseball (MLB) contributed $1 million to the cause during Saturday's event -- adding to a total contribution of $11 million -- which was billed as a preliminary event for Tuesday's All-Star Game.
In addition to the free concert, Crowe sang the national anthem for Tuesday's game. President Obama also threw out the ceremonial first pitch.
Crow, a Missouri native, told "Early Show" co-anchor Harry Smith the experience of performing in the Cardinals new Busch Stadium for both Stand Up to Cancer and the All-Star game was "great."
"I think just the attention that the All-Star game brings to what cancer does is huge," Crow said. "You couldn't buy air time like that."