Microneedle Flu Shots: "Pain Free" Patch on The Way, Say Scientists

vaccination needle, caudecus, flu shot AP

A microscopic image of dissolving microneedles, shown here encapsulating a pink dye to simulate how a vaccine would be incorporated into the needle. (AP)
A microscopic image of dissolving microneedles, shown here encapsulating a pink dye to simulate how a vaccine would be incorporated into the needle. (AP)

(CBS/AP) One day your annual flu shot could come in the mail.

At least that's the hope of researchers developing a new method of vaccine delivery that people could even use at home: a patch with microneedles.

Microneedles?

That's right, tiny little needles so small you don't even feel them. Attached to a patch like a Band-Aid, the little needles barely penetrate the skin before they dissolve and release their vaccine.

Researchers led by Mark Prausnitz of Georgia Institute of Technology reported their research on microneedles in Sunday's edition of Nature Medicine.

The business side of the patch feels like fine sandpaper, he said. In tests of microneedles without vaccine, people rated the discomfort at one-tenth to one-twentieth that of getting a standard injection, he said. Nearly everyone said it was painless.

Some medications are already delivered by patches, such as nicotine for people trying to quit smoking. That's simply absorbed through the skin. But attempts to develop patches with the flu vaccine absorbed through the skin have not been successful so far.

In the Georgia Tech work, the vaccine is still injected. But the needles are so small that they don't hurt and it doesn't take any special training to use this kind of patch.

So two problems are solved right away - fear of needles, and disposal of leftover hypodermics.

"The goal has been a means to administer the vaccine that is patient friendly," Mark R. Prausnitz of Georgia Tech said in a telephone interview.

That means "not only not hurting or looking scary, but that patients could self-administer," he said, and people would be more likely to get the flu vaccine.

The patch is placed on the skin and left for 5 minutes to 15 minutes, he said. It can remain longer without doing any damage, he said. In tests on mice, the miocroneedles delivered a correct dose of the flu vaccine.

The researchers are seeking funds to begin tests in people and, if all goes well, the patch could be in use in five years, Prausnitz said.

Asked if the term "microneedle" might still frighten some folks averse to shots, Prausnitz said he was confident that marketers would come up with a better term before any sales began.

  • David W Freeman

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