With both teams already assured playoff spots, the Rockies cut the Dodgers' division lead to one game. Colorado needs to sweep the three-game series to win the West.
The Rockies won their fifth in a row and Dodgers lost their fifth straight.
Troy Tulowitzki hit a two-run homer and Yorvit Torrealba had a two-run double for the Rockies.
Dodgers star Manny Ramirez struck out all four times up, matching a career high. He fanned in the seventh inning with two runners on base.