Kanye, Sam Smith, Janet Jackson, the Who headlining iHeartRadio Music Festival

Kanye West, Sam Smith, Janet Jackson and the Who are some of the A-listers set for the iHeartRadio Music Festival this fall.

Lil Wayne, Coldplay, the Weeknd and Blake Shelton will also perform during the two-day event in Las Vegas on September 18-19, iHeartMedia announced Thursday.

The festival, in its fifth year, will take place at the MGM Grand Garden Arena. Ryan Seacrest will host the event.

Tickets go on sale Saturday for the general public.

Other performers include David Guetta, Kenny Chesney, Fall Out Boy, Disclosure, Duran Duran, Prince Royce, Diplo, the Killers and Jason Derulo.

The festival will live stream on Yahoo! and iHeartMedia's radio stations. It will air as a two-night special on The CW Network on September 29-30.

The festival will also include outdoor daytime performances at the MGM Resorts Village on September 19. Performers for the Daytime Village include Demi Lovato, Hozier, Tove Lo, Trey Songz, Walk the Moon, Nick Jonas, Big Sean, Lee Brice, Echosmith and James Bay.

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