Adel al-Zubeidi, representing former Iraqi Vice President Taha Yassin Ramadan, was shot to death and attorney Thamir al-Khuzaie was wounded in the ambush in the Adil neighborhood, according to lawyer Khamees Hamid al-Ubaidi.
Al-Zubeidi was the second defense attorney to be killed in less than a month.
Saddam's main lawyer, Khalil al-Dulaimi, blamed the government for Tuesday's attack. "The aim of these organized attacks is to scare Arab and foreign lawyers," al-Dulaimi said. "We call upon the international community, on top of them the Secretary-General of the United Nations, to send an investigative committee because the situation is unbearable."
CBS News correspondent Cami McCormick reports that al-Dulaimi insists both lawyers were killed by gunmen posing as Iraqi security forces.
A police general said the attack occurred when three gunmen in a speeding car pulled alongside the lawyers' vehicle and opened fire. The general spoke on condition of anonymity because the sensitive case was in the early stages of investigation.
Al-Zubeidi also represented Abdullah Kazim Ruwayyid, a former Baath party official. The trial opened Oct. 19 and was suspended until Nov. 28 to allow the defense time to prepare its case.
On Oct. 20, Saadoun al-Janabi, lawyer for co-defendant Awad al-Bandar, was abducted from his office by 10 masked gunmen. His body, with two bullet shots to the head, was found hours later on a sidewalk near Fardous Mosque in the eastern neighborhood of Ur in Baghdad.
"Security in Iraq is the main challenge to the trial of Saddam Hussein," says CBS News Foreign Affairs Analyst Pamela Falk, "and will cause delays in the proceedings and a likely request for a change in venue."
Saddam's defense team, which includes some 1,500 lawyers who act as advisers, is led by Khalid al-Dulaimi and Abdel Haq Alani, an Iraqi-born lawyer based in Britain.
In other developments: