Boreman was taken to Denver Health Medical Center with massive trauma and internal injuries after the April 3 accident, hospital spokeswoman Sara Spaulding said. She was taken off life support Monday, Spaulding said.
Boreman's ex-husband, Larry Marchiano, said he and their two adult children were at the hospital when she died.
"Everyone might know her as something else, but we knew her as mom and as Linda," Marchiano said. "We divorced five years ago, but she was still my best friend."
The family moved to Colorado in 1990 and the two divorced in 1996 after 22 years of marriage.
Boreman claimed her first husband forced her into pornography at gunpoint. They divorced in 1973.
Their relationship disintegrated into a life of violence, rape, prostitution and pornography, according to her 1980 autobiography, "Ordeal" and her testimony before congressional committees investigating pornography.
Boreman said she was never paid a penny for "Deep Throat" and her husband only was paid $1,250, though the film grossed a reported $600 million.
After leaving the industry, she traveled the lecture circuit on a crusade against pornography, speaking at colleges and with prominent feminists.
"I look in the mirror and I look the happiest I've ever looked in my entire life," she said in a 1997 interview. "I'm not ashamed of my past or sad about it. And what people might think of me, well, that's not real. I look in the mirror and I know that I've survived."
Boreman was born Jan. 10, 1949, in the Bronx borough of New York City.
By Colleen Long