Melanie is represented by a courtroom star, attorney Joe Tacopina. He and partner Steve Turano say Bill may have tempted his own fate.
"When you have money out on the street and you're behind and you're not making payments, you know what happens? You get shot here and you get shot here," Turano told the court in his opening statement, pointing at his chest and his head.
The state, the defense said, stubbornly focused only on Melanie. "There's no evidence that shows she did this. There's circumstances. There's no hard-core evidence," Tacopino said.
But the prosecutor argued the evidence, like the gun, the blanket, and the suitcases, are all "very compelling."
As the days went by, Melanie watched her life pass before her eyes, as people from her past testified. "They bring in people that I haven't seen in years," Melanie commented in her video diary. "It's like watching ghosts file into the room."
"The one thing that I'm struck by time and time again is that they talk about me like I'm dead," Melanie commented in her diary. When a former colleague said on the stand, "She IS a great nurse," Melanie later videotaped her reaction: "And I almost cried. I really almost cried. I hope it meant something to the jury. But I know it meant something to me."
In this case, the prosecutor says, the crime was cruel, and calculated. Prezioso believes Melanie drugged Bill before shooting him. She claims Melanie used a powerful sedative, chloral hydrate, obtained with a prescription that someone forged on the pad of Melanie's lover, Dr. Brad Miller.
But no evidence of the drug was found in Bill's body; the state argues his body was found too late to test.
Then there's the matter of the searches conducted on the McGuire home computer, just days before Bill disappeared. Search engine search terms, an investigator testified, included, "instant undetectable poisons," "how to purchase guns?" and "how to commit murder."
But, as the defense showed, that may not be as bad as it seems - the investigator acknowledged they had no idea who made those searches. "There are other searches. Seconds after the so-called incriminating search. Where it's a Web site or a site that only Bill McGuire could access. It's password protected," Turrano explained.
Prezioso admitted she cannot pinpoint when or even where the murder occurred but she has a theory that it happened in the apartment.
That apartment, particularly the bathroom, was painstakingly searched several times. All, to no avail: no forensic evidence was discovered. Prezioso shrugs that off, suggesting Melanie did a thorough cleaning job. "We have somebody who is very bright, who was doing computer searches and research on how to do this effectively," Prezioso argues.
Perhaps the strongest evidence against Melanie is the very story she herself has told, especially that part about coming to Atlantic City, looking for her husband. Remember, Melanie said that she found Bill's car and moved it out of spite. That would have been just hours before she filed a restraining order against him.
Why would she go down there?
"It's not logical. It's not logical at all. And I acknowledge that," Melanie tells Maher.
"Me moving his car is something that, you know, to anybody who knows me seems so natural and so me, you know. So passively spiteful. Yet at the same time not overtly confrontational. I just gotta wonder will the jury believe it, you know," Melanie said in her video diary.
Four weeks into the trial, Cindy Ligosh takes the stand. By now, she is Melanie's bitter enemy, and has temporary custody of Melanie and Bill's children.
"It was incredibly frustrating because she came off very sympathetically," Melanie noted in her video diary of Cindy's testimony. "To the point where when she was crying I started to cry."
The trial is taking its toll on Melanie, and she is feeling the wrath of the prosecutor. "With her, I'm scum. Did I sleep with her boyfriend in high school? Did I beat her for a role in the high school play?" she asks in her video diary.
But Prezioso says this was was not personal at all. "This was a murder trial. It wasn't a tea party. I wasn't there to become friendly with her. I was there to do my job," she says.