Quarterback Jeff George, the No. 1 pick in the 1990 draft, pulled his left groin with 50 seconds left in the first quarter.
Napoleon Kaufman, who had rushed for more than 100 yards twice in four previous games this season, turned his left ankle with 3:15 left in the third quarter.
Neither player returned to the game. Raiders coach Jon Gruden said George would be evaluated Monday, but is doubtful to play next week again AFC West rival San Diego.
He said Kaufman, injured on a 3-yard carry when he was tackled by Andre Wadsworth and Mark Smith, is day-to-day. Kaufman was walking along the sideline later in the game, but Harvey Williams finished at running back.
George, the No. 1 pick in the 1990 draft, was under pressure from Arizona's Andre Wadsworth on a rollout, but wasn't touched after he threw the ball away.
George was examined on the sidelines, and the top of his left thigh was bandaged. He was 4-for-10 for 16 yards and one interception in 14 minutes.
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