District Attorney Seth Williams says the charges come after a grand jury reviewed accusations referred by the Archdiocese of Philadelphia.
The charges involve sex acts that allegedly occurred from 1996 to 2000.
A former secretary of clergy is charged with felony endangerment. Prosecutors say he transferred abusive priests to new parishes with schools and youth groups without warning parish officials.
Two priests, a former priest and the teacher are charged with rape and related crimes.
A statement from Cardinal Justin Rigali says the archdiocese is cooperating with civil authorities in the investigation.