Ramirez hit three of Cleveland's five home runs, and the Indians rebounded from a tough loss to beat the Oakland Athletics 12-4 Wednesday.
"He can flat-out hit," Oakland's Jason Giambi said. "When he wants to, he can be the show all by himself."
"I just went out there, was patient and got my hands extended," Ramirez said. "I just got some good pitches to hit."
"We swung the bats well today and we got to use our power," Cleveland manager Mike Hargrove said. "Manny is a very special hitter. He can do things that make you shake your head and wonder, how can he do that."
Cleveland, which lost 11-10 Tuesday night in the opener of the two-game series, was 10-2 against Oakland this year.
Oakland, which began the day tied with Boston for firsin the AL wild-card race, had a season-high six home runs Tuesday night.
But Bartolo Colon (14-4) pretty much kept the A's in check, allowing three runs, four hits and five walks in seven innings. He is 7-1 in nine second-half starts.
Oquist was tagged for seven runs and seven hits in four innings.
"We died by the home run today," said Oakland manager Art Howe. "I thought the homer by Vizquel was the back-breaker."
"I do want to know how they circumvented the rules they had Manny Ramirez bat in every inning, or at least it seemed that way. But overall on this homestand we played .500-ball against two quality teams and hopefully we'll have a winning road trip that will keep us in this race."
Oakland went 3-3 during the six-game homestand against Cleveland and Toronto.
Richie Sexson hit a two-run double in the first but Giambi answered with a two-run double in the bottom half.
After Ramirez's first homer, Randy Velarde's third homer in two games made it 3-all in the third.
Thome, who had a grand slam on Tuesday night, led off the sixth with his 25th of the year and Vizquel added an RBI double.
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