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Is it OK to make babies from 3 parents' DNA?

The UK's House of Commons takes first step in legalizing a method that would create babies using DNA from three parents
UK lawmakers approve creation of embryos from 3 parents 06:05

Britain could soon become the first country to allow a controversial technique to create babies from the DNA of three people. Lawmakers in Parliament's House of Commons voted Tuesday to permit embryos to be genetically modified -- a move that could prevent children from inheriting potentially fatal diseases. The bill must next be approved by the House of Lords before becoming law.

The in-vitro fertilization technique involves altering a human egg or embryo before transferring it into the mother. Until now, British law had forbidden any such modification. So-called "three-parent IVF" is not approved in the United States, although the U.S. Food and Drug Administration is investigating its safety.

The British government published rules in December on how the techniques should be used. The U.K.'s Chief Medical Officer, Dr. Sally Davies, said they should be legalized "to give women who carry severe mitochondrial disease the opportunity to have children without passing on devastating genetic disorders."

The ethics of having three parents 05:24

Defects in the mitochondria can result in diseases including muscular dystrophy, heart, kidney and liver failure and severe muscle weakness.

Critics, however, say the techniques cross a fundamental scientific boundary, since the changes made to the embryos will be passed on to future generations. They have also warned the techniques could lead to the creation of "designer babies."

"(This is) about protecting children from the severe health risks of these unnecessary techniques and protecting everyone from the eugenic designer-baby future that will follow from this," said David King, director of the secular watchdog group Human Genetics Alert.

The techniques would likely only be used in about a dozen British women every year who have faulty mitochondria, the energy-producing structures outside a cell's nucleus. To fix that, scientists remove the nucleus DNA from the egg of a prospective mother and insert it into a donor egg from which the nucleus DNA has been removed. This can be done either before or after fertilization.

The resulting embryo would end up with the nucleus DNA from its parents but the mitochondrial DNA from the donor. Scientists say the DNA from the donor egg amounts to a fraction of a percent of the resulting embryo's genes.

The debate leading up to Tuesday's vote grew heated, reports CBS News correspondent Mark Phillips in London. "It would be hard to imagine a more controversial or passionate debate. There was a lot of loaded language in this ... 'designer babies,' 'playing God,' 'three-parent babies,'" Phillips said.

"The church has argued, other people have taken moral and ethical positions that this is unnatural, that it's wrong on ethical grounds, on moral grounds, on religious grounds -- even on medical grounds, because the trials aren't quite as extensive as some people would like to have seen them." However, he noted that the measure had safeguards built in to limit the practice to cases of preventing genetic disorders, and the final vote was strongly in favor of approval.

Dr. Gillian Lockwood, a reproductive ethicist, told the BBC it's a bit misleading to refer to the process as three-parent IVF: "In fact it is 2.001-parent IVF," she said. "Less than a tenth of one percent of the genome is actually going to be affected. It is not part of what makes us genetically who we are."

She also disputed claims that the technique could lead to designer babies. "It doesn't affect height, eye colour, intelligence, musicality. It simply allows the batteries to work properly," she said.

In the U.S. last year, the FDA held a meeting to discuss the techniques and scientists warned it could take decades to determine if they are safe. Experts say the techniques are likely being used elsewhere, such as in China and Japan, but are mostly unregulated.

Rachel Kean, whose aunt suffered from mitochondrial disease and had several miscarriages and stillbirths, said she hoped British politicians would approve the techniques. Kean, an activist for the Muscular Dystrophy Campaign, said her mother is also a carrier of mitochondrial disease and that she herself would like the option one day of having children who won't be affected.

"Knowing that you could bring a child into this world for a short, painful life of suffering is not something I would want to do," she said.

Lisa Jardine, who chaired a review into the techniques conducted by Britain's fertility regulator, said each case will be under close scrutiny and that doctors will track children born using this technique as well as their future offspring. She acknowledged there was still uncertainty about the safety of the novel techniques.

"Every medical procedure ultimately carries a small risk," she said, pointing out that the first baby created using in-vitro fertilization would never have been born if scientists hadn't risked experimenting with unproven methods.

Kean said she understood the opposition to the new technology.

"It's everybody's prerogative to object due to their own personal beliefs," she said. "But to me the most ethical option is stopping these devastating diseases from causing suffering in the future."

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