Steve Karsay was the losing pitcher in Cleveland's first game and didn't lose again until Toronto got to him in game 160.
Karsay (10-2) gave up a tiebreaking home run to Willis Otanez in the eighth inning as the Blue Jays hurt the Cleveland Indians' bid for home-field advantage throughout the AL playoffs with an 8-6 comeback win Friday night.
With two games left, Cleveland is tied with the New York Yankees at 97-63 for the best AL record.
Karsay had not lost since April 6 in Anaheim. He has been throwing mostly fastballs since returning Sept. 22 from his second stint on the disabled list with a strained right forearm.
"I just wasn't very good tonight, but I did throw some curveballs. I struck out (Tony) Batista with one," Karsay said.
It was a fastball that Otanez hit over the left-field wall for his sixth homer to break a 6-6 tie. Vernon Wells added an RBI double later in the inning.
"I knew I hit it good," Otanez said. "It was a 1-0 pitch and I was looking for a pitch middle-in. That's right where it was."
"The bullpen did a fabulous job tonight," Toronto manager Jim Fregosi said. "Every game is important to Cleveland, but we are going to play them tough."
Cleveland manager Mike Hargrove knew Toronto would not be easy to beat in the regular season's final series.
"I would much rather open the playoffs at home. To be assured of that w would have had to take four of four from Toronto. That is very difficult," he said.
Ramirez hit his 44th homer, a 445-foot shot to center, to give Cleveland a 5-2 lead in the fourth. Ramirez has 165 RBIs this season, tying Hall of Famers Al Simmons (1930) and Lou Gehrig (1934) for 12th on the all-time list.
Fryman's 10th homer sparked a three-run second. When he touched home plate, Cleveland became the first team with 1,000 runs since the 1950 Boston Red Sox.
Lofton and Fryman each had three hits.
Cleveland starter Dwight Gooden remained winless since July 28, yielding four runs on six hits and three walks over five innings. Gooden probably won't be on the Indians' postseason roster.
Tony Batista and Otanez had RBI singles in the first to put Toronto ahead 2-0. Cleveland made it 2-1 in the bottom half when Harold Baines drew a bases-loaded walk.
David Segui hit a two-run homer, his 14th, to pull Toronto within 5-4 in the fifth.
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