January 8, 2011 11:34 AM

Coroner Rules Jackson's Death a Homicide

(CBS/AP)  Michael Jackson's death was a homicide caused primarily by the powerful anesthetic propofol and another sedative, the coroner announced Friday in a highly anticipated ruling increasing the likelihood of criminal charges against the pop star's doctor.

The Los Angeles County coroner's office determined the cause of death was "acute propofol intoxication." Lorazepam, another sedative sold under the brand name Ativan, contributed to the death.

Additional drugs detected in Jackson's system were the sedatives midazolam and diazepam, the painkiller lidocaine and the stimulant ephedrine.

The coroner did not release Jackson's full autopsy report, citing a security hold requested by Los Angeles authorities investigating the case, and declined to comment beyond a short statement announcing the manner and cause of death.

"The findings are not a surprise but they do confirm that the singer had an awful lot of very strong medicine in his body when he died, a fact that clearly will help determine whether prosecutors now believe they have enough physical evidence to charge someone, including Jackson's treating physician Conrad Murray, with some sort of involuntary manslaughter charge," says CBS News legal analyst Andrew Cohen.

"The key here is not to get caught up in the use of the word 'homicide.' It does not mean we are going to see an intentional murder case here," Cohen notes. "It's just a generic word the medical examiner uses. When the prosecutor's office starts talking about terms like that we'll need to pay attention and I still think the most likely scenario here is an involuntary manslaughter charge against someone."

The coroner's determination of a homicide confirmed what The Associated Press first reported Monday, citing an anonymous law enforcement official.

The 50-year-old Jackson died June 25 at his rented Los Angeles mansion. Dr. Conrad Murray, the Las Vegas cardiologist who was the pop star's personal physician, told police he gave Jackson propofol that morning after a series of sedatives failed to help Jackson sleep.

Read CBSNews.com's complete coverage of Michael Jackson's life and death

Murray has not been charged with any crime but is the target of what police term a manslaughter investigation. Multiple search warrants served at his home and businesses in Las Vegas and Houston sought evidence detailing how he procured the propofol that killed Jackson. Jackson's interactions with at least six other doctors also are being scrutinized.

Except for a brief video posted to YouTube earlier this month, Murray has not spoken publicly since Jackson's death. In the video, he said: "I told the truth and I have faith the truth will prevail."

Murray's attorney, Edward Chernoff, said he was disappointed the full autopsy report wasn't released. Without that, it was impossible to seek independent expert opinion on the significance of the various drugs detected.

"Release the toxicology report, the whole thing. Sunlight is the best disinfectant," Chernoff said. "This smells like gamesmanship."

Chernoff repeated his assertion that nothing Murray gave Jackson "should have" killed him.

It's not clear when the full report may be released. The coroner said the security hold would remain until the investigation is wrapped up. The Los Angeles Police Department and the district attorney's office said they did not know when that would be.

A statement by the LAPD said the investigation into the death is ongoing and "will result in the case being presented to the Los Angeles County District Attorney for filing consideration."

The coroner's determination of homicide makes it more likely criminal charges will be filed but does not guarantee it. In the past seven years just a handful of doctors have been convicted of manslaughter, mostly involving their patients' use of painkillers. To win a conviction, prosecutors would have to show that Murray acted recklessly and with negligence.

Murray was hired by Jackson's promoter AEG Live to help keep the aging star fit during the grueling preparation for a series of comeback "This Is It" concerts in London. Jackson got to know Murray in Las Vegas, where he moved after a stint overseas following his 2005 exoneration on child molestation charges and where the Caribbean native ran a clinic.

It was a break — and a $150,000-a-month salary — that Murray desperately needed. The doctor hadn't paid the mortgage on his country club mansion in 2009, and according to court records he owed a total of at least $680,000 in judgments against him and his medical practice, delinquent student loans, child support and credit cards.

Murray has been interviewed twice by police. According to court records, he told investigators that over about six hours he injected Jackson with two doses each of lorazepam and midazolam. Finally, around 10:40 a.m., Murray said he succumbed to Jackson's demands and administered propofol, a drug Murray said he had given Jackson every night for six weeks. He said he had diluted the propofol with lidocaine.

Propofol, dubbed "milk of amnesia" among anesthesia professionals, commonly is used to render patients unconscious for surgery. It's only supposed to be administered by anesthesia professionals in medical settings and, because of its potency, requires the patient be closely monitored at all times. Using propofol strictly as a sleep agent violates medical guidelines.

Medical experts said the drugs found in Jackson's system magnify each other's effects.

"Instead of one plus one equals two, one plus one equals three," said Lee Cantrell, a toxicologist and director of the San Francisco division of the California Poison Control System.

A search warrant affidavit unsealed this week in Houston includes a detailed account of what detectives say Murray told them. The doctor said he'd been treating Jackson for insomnia for about six weeks with 50 milligrams of propofol every night via an intravenous drip, the affidavit said. Murray said he feared Jackson was becoming addicted to the anesthetic, which is supposed to be used only in hospitals and other advanced medical settings, so he had lowered the dose to 25 milligrams and added the sedatives lorazepam and midazolam.

That dosage is very small and by itself it's very unlikely it would have killed him. But with the other drugs there was a "benzodiazepine effect," according to the coroner, and it was deadly.

Dr. David Zvara, anesthesia chairman at the University of North Carolina at Chapel Hill, said it's difficult to determine what constitutes a fatal dose of propofol in someone receiving other sedatives.

"It's hard to set any level because of the way those act in synergy," he said. Given after the sedative lorazepam, "Even a small dose of propofol might have a very large effect."

Jackson had many medical procedures over the year and a long history with various drugs. Following his death, three medical professionals said Jackson asked them for propofol this spring. All refused. One, a registered nurse named Cherilyn Lee, recounted that Jackson told her he liked how the drug knocked him out fast and allowed him to sleep for hours longer than he could naturally.

Doctors were surprised by the coroner's mention of ephedrine, once sold as the controversial diet drug Ephedra and now banned by the federal Food and Drug Administration, though the drug can be used for resuscitation. Zvara said it's unlikely emergency personnel who responded to Jackson's home would have used that drug since epinephrine, otherwise known as adrenaline, is favored.

© 2011 CBS Interactive Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.
Add a Comment See all 39 Comments
by pickaguitar1 August 31, 2009 11:19 AM EDT
RIp Michael
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by pickaguitar1 August 31, 2009 10:42 AM EDT
RIP Michael
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by trapbreaking August 29, 2009 3:00 PM EDT
Jackson was a doper and dopers with gobs of money can always find a doctor to get it for them, or they can go offshore, or they can use their hang on groupies get the drugs.

.
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by thomasxstewa August 29, 2009 2:10 AM EDT
thomasxstewart wrote:

Murray commited homicide by obtaining control drugs in Las Vegas, Nv by writing false script with murray as patient. then traveling interstate to resell control narcotics at profit to Michael J. Jackson, in such low doseages as to insure Emotional dependance. with Lidocaine, which can cause extremely great cravings for more. Lidocaine is over counter drug used in Crack Cocaine manufacturer,
Lidocine is stimulant.

Big block to Homicide trial is DA itself. DA come up thru petty drug incursions & street level open air markets. Making conveants to avoid loss of own team extreme in calous nature. even though control Drug are Non tranferable, MD not To Profit from dispensation, Writing narcotics script in ones own name for onesself, & dispensing narcotic to drug addict ARE ALL FELONIES, Most DA don't have courage to enforce those laws. IUn Fact Da Orchestrate & Have commited More Deaths with Drug Weapons than many others.

DA Sells Priviledge & thats part of back room lawyer/Account dealing to manage highly paid "professionals", Da hopes to cull. More Boy Scout troupe than Legal Justice.

however, family Demands Prosecution & Coroner is willing to testify its' Homicide. Only FOOL wouldn't Start with greater charge & let jury decide if lesser charge is in order.

Signed:PHYSICIAN THOMAS STEWART von DRASHEK M.D.


Posted by: thomasxstewart | August 24, 2009 at 09:09 PM

8/25/2009 12:24 AM EDT
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by MySay2 August 29, 2009 12:06 AM EDT
yoyoinla, That is not a rebuttal it is simply incorrect information.

1. Dr. Murray is a DOCTOR/PROFESSIONAL, he attended a school of medicine to obtain licensing in medicine.

2. As a Doctor Murray swore by the Hippocratic oath which partly states ethically taking care of a patient nursing him/her back to good health.

3. Dr. Murray did not do an assessment on his patient to find out what his problem was he allowed the patient to dictate the problem to him

4. Dr. Murray allowed the patient to tell him what type of medication to give him, There is no such thing as a patient telling the Doctor what he should give him.

5. Dr. Murray DID NOT have a license in CA to dispense medication nor to write prescription for medication.

6. Dr. Murray obtained medication used for sedation ONLY in an operating room of a hospital or outpatient of a clinic

7. Dr. Murray used a medication which is ONLY to be used by an anesthesiologist or nurse anesthetist only these professionals are authorized to use this medication.

8. Dr. Murray not authorized to dispense medicine, not authorized to use propofol used propofol in a home environment.
Dr. Murray used propofol which is a sedative of operation as a means of treating insomnia

9. Dr. Murray had NO life saving equipment or monitoring equipment REQUIRED for administering this medication, notice, this equipment is REQUIRED.

10. Dr. Murray gave his patient various drugs 2 to 3 times in a very narrow time frame without regard to their interaction.

11. Dr. Murray left his patient unattended which should never be done under any circumstance while under the influence of this medication.

12. Dr. Murray found his patient DEAD and did not call 911 for more than an hour yet he managed to call other places first.

13. Dr. Murray refused to sign the death certificate as though is he didn't sign it than Michael Jackson didn't die at home but he died at the hospital under the care of the paramedics.

Now allow me to further educate you. No matter who a patient is, how much money a patient has, or how demanding a patient is. THE PATIENT ACTIONS DOES NOT NEGATE THE RESPONSIBILITY OF THE DOCTOR WHO IS THE PROFESSIONAL. There is no cause an effect when it comes to the demands of a patient and the action of the Doctor.

Michael Jackson was not Dr. Murray's client, HE WAS DOCTORS MURRAY'S PATIENT. Therefore Dr. Murray had the responsibility to nurse his patient back to good health and if his patient was requesting medicine which was off limits, the Doctor's responsibility was to deny the patient.
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by yoyoinla August 31, 2009 2:36 PM EDT
Uh, excuse me. Please direct your comments to the place they belong. I'M ON YOUR SIDE. I don't need to be "educated". I believe you are directing your ire at the intelligent Pensacola, who is equally educated, I would suspect, but looks at this from a different perspective. (I say that seriously, by the way).
by ccrn1234 August 28, 2009 10:06 PM EDT
Ok. So this "Doctor" is totally unethical for administering these drugs at Jackson's home. Any idiot should know nit is not enough to monitor his O2 Saturation. That is often the last thing to decrease. Your sat can be fine till you actually stop breathing meanwhile the CO2 level is climbing till eventually you stop breathing. Was it worth it to the doctor to sel his sole and life for 100,000 a month. He should have know better. If Jackson needed those kinds of meds he needed hospitalization. Probably needed electroshock therapy too.
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by Nitcroler August 28, 2009 9:43 PM EDT
Although it may be right that Michael Jackson is dead. But recently I was browsing through the web and I came accross a web site which I cannot remember, it shows someone wearing a white shirt, long black hair leaving the back of the coronary van and taken inside the building. If Jackson died wearing a white shirt, which I wouldn't know, then maybe there is some truth in it. And I am still puzzeled about the called that was made to 911, the person calling didn't mentioned it was Michael Jackson. There are rumors that did spread after Elvis Presley died, only rumors.
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by knowdalaw August 28, 2009 6:59 PM EDT
I agree with Dr. Murray's attorney. Release the whole toxicology report. Release the Full autopsy report. What are they afraid of? What are they holding back?
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by scabbard2 August 28, 2009 6:56 PM EDT
Jesse and Al are probably the biggest loosers here...no one to rail against, well maybe the doctor, but he's black.
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by ivehadit9 August 28, 2009 6:51 PM EDT
See, when I become a medical doctor I wouldn't associate myself whatsoever with some celebrity, because you never really know what's gonna happen to you. When that celebrity finally says "au revoir" for all eternity, you never know what's gonna happen to you. Now, Conrad Murray is facing prosecution and, perhaps, jail time, although I doubt he'll serve a day in prison. But even then, his notoriety of causing MJ's death will be there forever. It's highly doubtful if he'll practice medicine again. Why was he dumb enough to associate himself with MJ in the first place, I don't know, except for the glory.
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