WASHINGTON, Dec. 3, 2008
Asthma Inhalers Set To Go Green
Medicine In The Inhalers Isn't Changing, But Chemicals Used To Deliver Drugs Into Lungs Is
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(CBS/AP)
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The medicine inside these rescue inhalers — the albuterol that quickly opens airways during an asthma attack — isn't changing. But the chemicals used to puff that drug into your lungs are.
No more chlorofluorocarbons, or CFCs, that damage Earth's protective ozone layer. By year's end, all albuterol inhalers must be powered by the more eco-friendly chemical HFA, or hydrofluoroalkane.
The down side: The new inhalers cost more, $30 to $60 compared to as little as $5 or $10 for the disappearing generic CFC inhalers.
And patients face a learning curve. HFA inhalers must be used differently than the old-fashioned kind. The medicine feels and tastes different, sometimes alarming new users despite doctors' assurances that it works just as well.
"There's still significant confusion," says Dr. Harvey Leo of the University of Michigan's C.S. Mott Children's Hospital. "Patients will tell you, 'I don't feel the puff anymore."'
Calls from parents unsure how to use the new inhalers, or even what they are, have increased in the past two months as more drugstores run out of CFC-powered inhalers and automatically switch people who'd been expecting a mere refill, he adds.
The change shouldn't be a surprise. The Food and Drug Administration has long warned it was coming, and lung specialists have spent the past year easing many of the nation's 20 million asthma patients — as well as millions of emphysema sufferers who also use albuterol to ease breathing — into it.
But industry figures show that in mid-November, 20 percent of all albuterol prescriptions still were being filled with CFC versions.
Some patients may purposefully be buying up cheaper CFC inhalers before the sales ban. But many patients don't see a lung specialist, or their prescription may not expire until next year so they haven't been seen recently enough to be told.
Reaching the last fraction "is, as you can imagine, a very difficult task," says Dr. Bidrul Chowdhury, FDA's pulmonary drugs chief. "How to get to somebody who is not tuned in?"
The CFC-free options: GlaxoSmithKline's Ventolin HFA, Schering Plough's Proventil HFA and Teva Specialty Pharmaceuticals' ProAir HFA all contain albuterol. Also, Sepracor's Xopenex HFA contains the similar medication levalbuterol.
Albuterol inhalers are for emergencies, for quick relief of wheezing. Patients also need daily medication to control their asthma and prevent flare-ups. Someone who's using the albuterol inhaler more than a few times a month isn't well-controlled, and his or her doctor needs to determine why, stresses Dr. Paul Greenberger of Northwestern University, president-elect of the American Academy of Allergy, Asthma & Immunology.
Here's the rub: Recent research suggests only one in five children has their asthma under good control; no one knows how many adults do.
The last to go CFC-free will be the poor and uninsured whose asthma is less likely to be controlled, says Leo, who researches that issue at Michigan's Center for Managing Chronic Disease.
Albuterol manufacturers are providing free samples and posting coupons on their Web sites.
Still, specialists worry that some patients will try to save money with a decades-old nonprescription inhaler that contains a different drug, epinephrine, best known by the brand name Primatene Mist — inhalers that also contain ozone-harming CFCs. National asthma guidelines argue against such self-treatment as too risky and less effective than albuterol. The government will allow sale of those over-the-counter inhalers until December 2011 as manufacturers reformulate.
Leo has another concern: Only one of the new inhalers counts doses used. He's monitoring emergency-room statistics to see if cost-conscious patients trying to squeeze out last drops wind up using empty inhalers.
What do patients need to know as they switch?
"They are getting their medicine," says Dr. David Rosenstreich of New York's Montefiore Medical Center. "They have to get used to it and be aware that it's working."
The FDA says there's plenty of supply; it gave manufacturers several years to ramp up before the ban.
But don't wait until the last minute. When Eric Stoermer of Ann Arbor, Mich., made the switch in August, he waited a week for a new inhaler for his 11-year-old son Ethan. Their drugstore was temporarily out of stock.
"I ended up having to hunt around on an emergency basis," Stoermer says. "This is a bad thing to run out of."
By Lauran Neergaard
© MMVIII The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.
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- The "green" folks who launched the campaign against "fluorocarbons" (ozone hole) at the same time they launched the Global Warming campaign have been warning us that "sacrifices will be necessary." Looks like now it''s time to sacrifice ggm1957''s son to the god of ozone.
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- Vermont made this change already and my son uses an asthma inhaler. The new ones do not work anywhere near as well. I can understand the going green, but then what about all of the "toys" - like the 4 wheelers and snowmobiles that are not necessary. How about doing something about the pollution caused by those machines instead of something like inhalers?
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