Red Wine A Weapon In Battle Of The Bulge
An antioxidant found in red wine and grapes known as resveratrol - already thought to help keep the heart healthy and ward off cancer - may also turn out to be a fat fighter, according to new research.
In the laboratory, exposure to resveratrol prevented pre-fat cells, termed pre-adipocytes, from increasing and from converting into mature fat cells, according to Martin Wabitsch, MD, PhD, a researcher from the University of Ulm in Ulm, Germany. Wabitsch presented the findings this week at ENDO 08, The Endocrine Society's 90th annual meeting in San Francisco.
"We have to show it works in the same way in human beings," Wabitsch tells WebMD.
The hope, he says, is to continue the research and, if it bears out, develop drugs that will use the same mechanism as the resveratrol in controlling the fat cells.
Health Benefits of Resveratrol: Study Details
In previous research, Wabitsch and his colleagues had found that the
resveratrol protected lab mice fed a high-calorie diet from the health problems brought on by obesity by mimicking the effects of caloric
restriction.
So the next step, they thought, was to see if the substance could mimic the effects of caloric restriction in human fat cells by changing them.
"We used a human fat cell strain," Wabitsch says, a stable cell strain that can be used over and over in the laboratory.
They exposed some fat cells to resveratrol and did not expose a comparison group of fat cells to the antioxidant. "Forty hours is the normal doubling time [of pre-fat cells]," Wabitsch says. "At 48 hours, the pre-fat cells in the control dish had more than doubled. In the resveratrol dish, the number of pre-fat cells had decreased by 40% to 45%," he tells WebMD.
The volume of fat cells exposed to the resveratrol was also less, he says, in effect producing skinnier fat cells. Exposure to the resveratrol also reduced the secretion of substances called interleukin 6 and 8, which may be linked to the development of diabetes and clogged arteries, both thought to be obesity-related problems.
Wabitsch says the finding is consistent with the theory that red wine's resveratrol explains the so-called French paradox - the observation that French people, who eat a relatively high-fat diet but enjoy their red wine, have a low death rate from heart disease.
Health Benefits of Resveratrol: What's the Mechanism?
The resveratrol affects the fat cells in many ways, Wabitsch says.
"There's not just one mechanism."
"The reduction of the number of pre-fat cells works through SIRT1," says Wabitsch, referring to the activation of a gene associated with metabolism and aging.
When they "silenced" SIRT1 in animal studies, the resveratrol had no effect on the proliferation of the pre-fat cells, he says.
The study was partly funded by the German Research Association and the
Ministry of Science, Research and Arts in Germany.
Health Benefits of Resveratrol: More Research Needed
The study is interesting, says Katherine Tallmadge, RD, an American Dietetic Association spokeswoman. "But we need more studies," she says.
She says that not enough is known about caloric restriction. Caloric restriction reduces body fat, which has multiple benefits, she says. But if it is too severe it can also be accompanied by health problems, including osteoporosis, she says.
Health Benefits of Resveratrol: The Future
When more is known about how resveratrol might inhibit fat, the hope is to develop a drug that will mimic the resveratrol's action, Wabitsch says. The pharmaceutical industry is already working on the concept, he says.
By Kathleen Doheny
Reviewed by Louise Chang
?2005-2008 WebMD, LLC. All rights reserved
© 2008 WebMD, LLC.. All Rights Reserved. In the laboratory, exposure to resveratrol prevented pre-fat cells, termed pre-adipocytes, from increasing and from converting into mature fat cells, according to Martin Wabitsch, MD, PhD, a researcher from the University of Ulm in Ulm, Germany. Wabitsch presented the findings this week at ENDO 08, The Endocrine Society's 90th annual meeting in San Francisco.
"We have to show it works in the same way in human beings," Wabitsch tells WebMD.
The hope, he says, is to continue the research and, if it bears out, develop drugs that will use the same mechanism as the resveratrol in controlling the fat cells.
Health Benefits of Resveratrol: Study Details
In previous research, Wabitsch and his colleagues had found that the
resveratrol protected lab mice fed a high-calorie diet from the health problems brought on by obesity by mimicking the effects of caloric
restriction.
So the next step, they thought, was to see if the substance could mimic the effects of caloric restriction in human fat cells by changing them.
"We used a human fat cell strain," Wabitsch says, a stable cell strain that can be used over and over in the laboratory.
They exposed some fat cells to resveratrol and did not expose a comparison group of fat cells to the antioxidant. "Forty hours is the normal doubling time [of pre-fat cells]," Wabitsch says. "At 48 hours, the pre-fat cells in the control dish had more than doubled. In the resveratrol dish, the number of pre-fat cells had decreased by 40% to 45%," he tells WebMD.
The volume of fat cells exposed to the resveratrol was also less, he says, in effect producing skinnier fat cells. Exposure to the resveratrol also reduced the secretion of substances called interleukin 6 and 8, which may be linked to the development of diabetes and clogged arteries, both thought to be obesity-related problems.
Wabitsch says the finding is consistent with the theory that red wine's resveratrol explains the so-called French paradox - the observation that French people, who eat a relatively high-fat diet but enjoy their red wine, have a low death rate from heart disease.
Health Benefits of Resveratrol: What's the Mechanism?
The resveratrol affects the fat cells in many ways, Wabitsch says.
"There's not just one mechanism."
"The reduction of the number of pre-fat cells works through SIRT1," says Wabitsch, referring to the activation of a gene associated with metabolism and aging.
When they "silenced" SIRT1 in animal studies, the resveratrol had no effect on the proliferation of the pre-fat cells, he says.
The study was partly funded by the German Research Association and the
Ministry of Science, Research and Arts in Germany.
Health Benefits of Resveratrol: More Research Needed
The study is interesting, says Katherine Tallmadge, RD, an American Dietetic Association spokeswoman. "But we need more studies," she says.
She says that not enough is known about caloric restriction. Caloric restriction reduces body fat, which has multiple benefits, she says. But if it is too severe it can also be accompanied by health problems, including osteoporosis, she says.
Health Benefits of Resveratrol: The Future
When more is known about how resveratrol might inhibit fat, the hope is to develop a drug that will mimic the resveratrol's action, Wabitsch says. The pharmaceutical industry is already working on the concept, he says.
By Kathleen Doheny
Reviewed by Louise Chang
?2005-2008 WebMD, LLC. All rights reserved
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9 Comments Add a Comment
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- Sounds interesting...the only problem is that I don't like wine......
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- This is the best news I''ve read all week. I am hoping to drink a glass of vino every day now. I''ll keep you posted how I do. I also noticed this now in supplements, wondering if the same data pertains.
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- Cabernet''s humm, so good for you.
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- Since the Dr. Sinclair study was published in Nature a flood of dubious companies have sprung up selling resveratrol. One even makes his capsules in a rented house in Florida. Consumer Lab, an independent testing authority, evaluated the major brands and found many lacking in content and quality. The ones that passed their evaluation were Biotivia, Transmax and Bioforte. A product by Life Extension Co. failed badly with only 26% of the claimed resveratrol. Another brand, Revatrol, had virtually no trans-resveratrol in its supplement. The ConsumerLab test results are available on their web site. Most of the companies to avoid have some variation of the word resveratrol in their name and sell only one or two products.
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- Of course, they have to develop a drug to mimic the effects, couldn''t possibly use natural resveratrol. That would make it a supplement, right? No FDA approval or prescription required.
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- Came here in 1905, Grandfather, Dago Red Wine, passed on at 89. Grandmother, born in 1881, Dago Red Wine, passed on in the year 1985. What can I say, 71, Dago Red Wine, entering my comment.
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- Ever noticed a young wino? Hey they''re all old guys.
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- More disinformation from the right arm of Big Pharma, WebMD. The liver should always be an afterthought according to their philosophy.
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- Sounds suspicious......but I''m willing to try it! Glug glug glug.....
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