ATLANTA, May 28, 2008

New Intestinal Superbug On The Rise

Study Shows Cases Of Antibiotic-Resistant Infection Increasing By 10,000 Every Year

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    Clostridium Difficile, or "C-diff," is known as a "superbug" because it is resistant to some antibiotics. Almost 300,000 people have been hospitalized for it since 2005. Dr. Jon LaPook reports.

  • Video CDC Warns Of Superbug Surge

    A new study by the Centers for Disease Control is warning of an intestinal superbug surge. The number of C. diff infections has increased dramatically in recent years. Dr. Emily Senay reports.

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(CBS/AP)  The number of people hospitalized with a dangerous intestinal superbug has been growing by more than 10,000 cases a year, according to a new study.

The germ, resistant to some antibiotics, has become a regular menace in hospitals and nursing homes. The study found it played a role in nearly 300,000 hospitalizations in 2005, more than double the number in 2000.

The infection, Clostridium difficile, is found in the colon and can cause diarrhea and a more serious intestinal condition known as colitis. It is spread by spores in feces. But the spores are difficult to kill with most conventional household cleaners or antibacterial soap.

C-diff, as it's known, has grown resistant to certain antibiotics that work against other colon bacteria. The result: When patients take those antibiotics, competing bacteria die off and C-diff explodes.

"It's getting more frequent and harder to treat, but I should say, still treatable," said CBS News medical correspondent Dr. Jon LaPook. "What happens is your colon is filled with trillions of bacteria but they're in balance. If you take antibiotics, sometimes it throws the bacteria out of whack.

"This is spread in hospitals from room to room by doctors and nurses who can spread it from patient to patient," LaPook added.

This virulent strain of C-diff was rarely seen before 2000.

"The nature of this infection is changing. It's more severe," said Dr. L. Clifford McDonald, a Centers for Disease Control and Prevention expert who was not part of the study.

There are other factors that play into the rise of C-diff cases as well, including a larger number of patients who are older and sicker. "And there may be some overuse and inappropriate use of antibiotics," said Dr. Marya Zilberberg, a University of Massachusetts researcher and lead author of the study.

Quote

This is not a time for alarm, but more a time for educating health professionals to understand this particular pathogen.

Kathy Warye, Assoc. for Professionals in Infection Control and Epidemiology
The Zilberberg study was based on a sample of more than 36 million annual discharges from non-governmental U.S. hospitals. That data was used to generate the study's national estimates.

The research is being published in the June issue of Emerging Infectious Diseases, a CDC publication.

Using other scientists' estimates, the study concluded that 2.3 percent of the cases in 2004 were fatal - about 5,500 deaths. That was nearly double the percentage of C-diff-related cases that ended in death in 2000.

Many of the people who died had other health problems. The study did not try to determine if Clostridium difficile was the main cause of death in each case, Zilberberg said.

But earlier research concluded the infection is the underlying cause of thousands of deaths annually, and the problem is getting worse.

C-diff has become an acute health concern in Canada, where it was blamed for 260 deaths at seven Ontario hospitals recently, and 2,000 deaths in Quebec since 2002.

The Association for Professionals in Infection Control and Epidemiology is currently working with U.S. hospitals to study prevalence of the infection and what infection control measures seem to work best.

"This is not a time for alarm, but more a time for educating health professionals to understand this particular pathogen," said Kathy Warye, chief executive of the Washington, D.C.-based association.

© MMVIII, CBS Interactive Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.

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by Renegade.Rivers May 28, 2008 12:55 PM PDT
What this article failed to disclose is that there is a belief by more than just a few doctors that genetically altered foods may be one of the main culprits in this problem. Do this search on Google if you do not believe me: "c-diff and genetically altered foods."

Of course, it doesn''t surprise me that CBS will not disclose that genetically altered food is believed to be the cause of this, since Monsanto is a major advertiser on CBS.
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by Wookiee-1138 May 28, 2008 2:24 PM PDT
I keep telling people not be germophobes who keep using hand sanitizer every five minutes. But everyone always scoffs and tells me what a dirty boy I am.
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by mrykthy May 28, 2008 3:20 PM PDT
Last year my 86 yr old mother broke her hip, acquired C-diff in the hosp, and went to the nursing home with it. It wasn''t actually diagnosed for over a month, after my sister and my persistence that they find out why she had continually diarrhea. We watched aides go in and out of rooms helping patients w/o using/changing gloves. There was anti-bacterial gel in every room and hallway, but I never saw it used. It was probably six weeks before the infection was diagnosed and treated, and in my mother''s weakened state she contracted a respiratory infection that she was unable to fight and died. I didn''t see the doctor, the nursing staff, the nursing home management or aides take this illness seriously. Hopefully, they will now. Hopefully, other families will be saved the grief of losing a loved one needlessly.
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by boffo1962 May 28, 2008 4:59 PM PDT
Lay off the hand sanitizer, people!

If you''ve gotten rid of 99% of the bacteria on the first use, you''re making the remaining 1% stronger... And so it will go!
Reply to this comment
by brainteaser2 May 28, 2008 5:10 PM PDT
There is nothing new about C.difficle. It first became a hospital/health care facility problem in the ''80s. It stems from use & overuse of antibiotics. Patients and doctors brought this on themselves by the insistence that all infections viral, bacterial etc. had to have antibiotics. Lack of us of sanitation is largely responsible for other horrible infections such as MRSA.
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by usbrit-2009 May 28, 2008 5:13 PM PDT
Lay off the hand sanitizer, people!

If you''''ve gotten rid of 99% of the bacteria on the first use, you''''re making the remaining 1% stronger... And so it will go!

Posted by boffo1962

And that is called ......... EVOLUTION!!!!
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by estabwary May 28, 2008 5:41 PM PDT
C-diff has been around for 20 years & has been virulent. I used to beg dietary in nursing homes
to load people up with yogurt and ask floor nurses
to get probiotic orders when residents were put on
antibiotics. That idea was "too far out".
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by cfin5 May 28, 2008 6:08 PM PDT
Here''s a vein you can dig into for the cause. Al Gore and Monsanto Corp., the sole vendor of the artificial growth hormone drug "rBGH" or "Posilac" that they inject milk cows with is causing the cows problems. The farmers then use stronger and stronger antibiotics to treat these problems,.....while still milking the cow. HELLO? ANY MENTAL LIGHT BULBS ON YET? In the meantime, better start drinking only certified organic milk. Australia, New Zealand, Canada, to name a few countries are wise in prohibiting this garbage you put into your intestines. Still trust Al Gore? That dude is nothing but a Reverend Sharpton for the environmental movement. He just gets in the way to make a buck.
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by connietoscan May 28, 2008 7:13 PM PDT
my 18 yr old son is right now in cooper hospital fighting injuries caused by a fall from a 3 story balcony. he aquired c-diff and mrsa from being in the truama unit. he''s been there since 4/23 and still has both infections. none of coopers staff will talk to me about it. i''m pissed off and i don''t know what to do. any ideas?
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by barbaraf4 May 28, 2008 7:52 PM PDT
I don''t go so far as to be the restroom monitor; however, if I really must use a public restroom, I touch as few surfaces as possible and I open the door with the paper towel I used after washing my hands.
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by alanrobisch May 28, 2008 8:00 PM PDT
my wife had c dif and survived in fact had little problem with it. she got while hospitalized and then in nursing home. Face it guys our overuse of anti biotics not drinking milk is the problem and note also that the best chance of getting these serious infections are in hospitals because that is where the sickest people are. I found it interesting that someone said we should follow canada''s example yet they have the same trouble.

Note I saw my wife daily and did not get sick.
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by impeach_w May 28, 2008 8:12 PM PDT
cfin5, Why is Cdiff targeting a large pecentange of Canadians if they don''t use antibiotics on Cows?
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by veteran72 May 28, 2008 8:47 PM PDT
Rovian Buttweasles......Impossible to get rid of....
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by mainemade May 28, 2008 8:58 PM PDT
As an employee of a nursing home, part of the environmental services team, I have dealt up close and personal with C-diff on many occasions. I have been well trained to work in and around a C-diff room. ALL of my residents, and I stress this ALL, have gotten this condition while at a HOSPITAL and on high doses of ANTI-BIOTICS. As frail as my ''people'' are NONE have died from C-diff. Never have we had any resident to resident or resident to staff infections. This is because we all take extra care in hygenic practices.
Also, too much of that hand sanitizer stuff isn''t good either. Nothing is as good as warm water and soap handwashing! That is the biggest defense any of us have over these "Superbugs" such as C-diff and MRSA.
Handwashing, Handwashing, Handwashing.....It''s really simple....
Reply to this comment
by cfin5 May 28, 2008 9:04 PM PDT
impeach_w,.......Where did I say Canadians do not use antibiotics in cows? I did say that rBGH was banned there. My opinion is concerning America, not Canada......What will a constant ingestion of antibiotics from whatever source do to you?
Reply to this comment
by wardoglrs May 28, 2008 9:12 PM PDT
The Neo Con cure for humanity.
If we can kill them they will come....
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by louieptuey May 28, 2008 10:00 PM PDT
*** global warming.
Reply to this comment
by cfin5 May 28, 2008 10:01 PM PDT
my 18 yr old son is right now in cooper hospital fighting injuries caused by a fall from a 3 story balcony. he aquired c-diff and mrsa from being in the truama unit. he''''s been there since 4/23 and still has both infections. none of coopers staff will talk to me about it. i''''m pissed off and i don''''t know what to do. any ideas?

Posted by connietoscan at 07:13 PM : May 28, 2008--------The first thing I''d do if it were my son in that condition is get him out of there and have him start taking 100% wild Mediterranean "Oregano Oil" orally. Google it for yourself. Those doctors will kill your child just to milk your wallet dry.
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by louieptuey May 28, 2008 10:03 PM PDT
*** global warming.
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by enlightenu May 28, 2008 10:05 PM PDT
Posted by connietoscan at 07:13 PM

I recommend giving him bovine colostrum. it is available in tablets. if he takes 2 of these a day it will soon strengthen his immune system enough to fight it on its own. Thats the theory, but I have great confidence that it could work. I was prone to stomach viruses and ear infections, nearly on cue. Since I started taking the colostrum, I haven''t been sick since...about 2 years now. It is very safe and is classified as a food.
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by enlightenu May 28, 2008 10:12 PM PDT
Actually since these are naturally symbiotic bacteria already living in our bodies, then the immune system might not attack them, even if they are out of balance. Therefore strengthening the immune system might not be effective at all. Very scary. Can anyone clarify?
Reply to this comment
by cfin5 May 28, 2008 11:07 PM PDT
connietoscan,.....Talked to my wife about it because I couldn''t remember the name of the company. She said it was "Oreganol" from the North American Herb and Spice Co. We''ve used it on bad cuts and the like. Makes it heal up REALLY fast. God bless your son.
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by hermitdave May 28, 2008 11:52 PM PDT
Could this by chance be something brought to us by the same gang of science criminals that brought us AIDS? Perhaps part of the heaven on earth plan of a world with no homosexuals or non whites, now adding no old people.
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by wrhurt May 29, 2008 1:04 AM PDT
Who cares how many people die as long as the drug companies don''t make enough money to fund research and development? If the leftist loons hadn''t spent so much time, effort and money agitating against the drug industry in Congress, this whole debacle could probably have been prevented. Sadly, the diseases they have perpetuated by their fanatical attacks on the drug companies will not limit themselves to the left. They will kill us all. But for the loons, it''s okay, because letting the drug companies make a profit so they can fund research and development of other drugs is to be stopped at all costs. And, no, I don''t work (and never have) in the drug industry.
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by hermitdave May 29, 2008 1:57 AM PDT
Gosh Hurt your story is as touching as the one about those poor oil company CEO''s whining that they need those zillions to ward off bad times. I notice the drug companies have plenty of money to run ads telling the people to tell their doctor they need more pills.
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by nonayabiness May 29, 2008 2:46 AM PDT
"my 18 yr old son is right now in cooper hospital fighting injuries caused by a fall from a 3 story balcony. he aquired c-diff and mrsa from being in the truama unit." Posted by connietoscan

-My goodness, how did he fall off a 3 story balcony? Sounds like he''s lucky to be alive in the first place. I wish you all the best and hope everything works out.
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by nonayabiness May 29, 2008 2:49 AM PDT
Sometimes I think some of these stories are more hype than fact. That was, until my spouse and I both got Norovirus one year. Boy, was that ugly.

My kid got MRSA from daycare. Again, very scary.

I told doctors at my college nearly 20 years ago that antibiotics were''nt working anymore. They didn''t believe me. Now, guess what??
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by drrbar-2009 May 29, 2008 3:51 AM PDT
Alright to clarify because this article is horrible: I am a biological researcher and I work with human pathogens and have given a seminar to doctors on the treatment and problems associated with C. difficile (which i have never heard anyone call C. diff) Anyway it resides in 5% of adults and 66% of infants(not a problem for infants) natural flora of their digestive tract and is asymptomatic. It is only ever a problem if doctors dont perform the appropriate lab work and prescribe wide spectrum antibiotics.

Wide spectrum antibiotics kill everything in your intestins and then spores from external c. diff can make it through your digestive system and multiply at a fast rate due to the lack of competition. At this point the usually benign toxins they secrete build up and can penetrate your intestinal linings, if these bacteria make it into your bloodstream their s-layer proteins can give you sepsis (i.e coagulation of all your blood and massive organ failure).

The only people who need to be worried about this are those who have taken wide spectrum or anaerobic specific antibiotics and the elderly like the article says and who have been or currently are in the hospital. It has created epidemics that have closed entire hospitals due to improper cleaning and quarantine by hospitals. However for the average person this is nothing to worry about.
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by drrbar-2009 May 29, 2008 3:53 AM PDT
THINGS YOU CAN DO TO PREVENT SUCH INFECTION:
DO NOT TAKE WIDE SPECTRUM ANTIBIOTICS unless you have an MRSA infection and use for that use teicoplanin not vancomycin as c. diff is partially resistant. Ask for limited spectrum antibiotics if available
DO NOT USE ANYTHING WITH TRICLOSAN!!!! THIS SELECTS FOR ANTIBIOTIC RESISTANT STRAINS OF BACTERIA (it is in toothpaste, antibacterial handsoap, all over, it should be illegal but the pharmaceutical lobbyists have to much influence in washington and in the court system at the moment although we are currently working on a lawsuit)
DO NOT STAY IN THE HOSPITAL UNLESS IT IS ABSOLUTELY NECCESSARY- this is only a nosocomial (hospital) infection
If your are prescribed wide spectrum antibiotics eat live culture yogurt or look into various pro-biotic foods/supplements as these will fill your intestines with other bacteria that will out comptete the c. difficile
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by drinuk May 29, 2008 5:06 AM PDT
Too many bloody pills and potions and Too many vaccines of untested junk. We never learned the lessons from the Thalidomide tragedy and we take the word of Big Pharma and their partners in the FDA on everything they push.

A year from now we will be asking who is going to pick up the bill for the damage caused by MMR and Gardasil. Had "They" have had their way, we would have vaccinated millions with the Bird Flu vaccine which has turned out to be a Dead Duck ! What Next !
The list is endless, their greed knows no end.
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by drinuk May 29, 2008 5:21 AM PDT
wrhurt. You are quite obviously a Big Pharma lobbyist. Your comments are pathetic, since when did Big Pharma pay for unbiased, honest research into anything they produce. They spend their vast profits on buying favour, the FDA and anyone in Washington useful to their business.

Their research is conducted on the sick and needy, when enough folks suffer death or serious side effects, they reluctantly pull their junk, leaving those effected to fight for years through the courts to obtain redress.

As an Industry they are Scum, life to them is Cheap !
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by ago5675 May 29, 2008 6:35 AM PDT
I was hospitalized early this year in critical condition. I had taken heavy doses of antibiotics after oral surgery. I was immediately quarentined and tested. The Doctors discovered that I had C-diff and treated me with probiotics. Be assured that C-diff is extremely serious and all precautions MUST be taken not only to prevent it, but to prevent the spread of it to family and friends. I have fully recovered but it was an extremely difficult time.
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by tootall10142 May 29, 2008 7:19 AM PDT
HERE! HERE! couldnot have said it better pys-war! aexccellent summary and wholly based on past seen results not conjecture.where were you in 04 when we neede a real man on the campaign or woman?
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by extremophil May 29, 2008 8:20 AM PDT
A great person once said "I never wash my hands in a public restroom, cause I figure that my d*ck is the cleanest thing in the room".
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by armydog2 May 29, 2008 10:07 AM PDT
C-diff is caused by mega doses of antibiotics that kills bacteria in the colon that are necessary. It generally affects the elderly or critically ill patients. Universal precautions [thorough handwashing] is the best way to prevent the spread of this and MRSA.
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by samrensho May 29, 2008 10:19 AM PDT
Keep ingesting meat/milk loaded with antibiotics and you automatically select for resistant strains of bacteria. Mission Accomplished
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by rf35 May 29, 2008 10:50 AM PDT
Keep ingesting meat/milk loaded with antibiotics and you automatically select for resistant strains of bacteria. Mission Accomplished

Posted by samrensho

It''s not the antibiotics in the meat and milk that''s creating resistant strains; it''s the antibiotics that were shoved down kids'' throats during the last few decades. Blame lies with moms who pressured doctors into prescribing antibiotics for viral colds/flues. The docs knew it had no effect on the kids; it just placated the parents who didn''t know any better. Instead of educating the parents, the medical practice happily took the extra money from the prescription antibiotics and sent the parents home thinking they had done something to cure their child of an incurable virus. There%u2019s a reason antibiotics are prescription-only drugs. Anyway, then mom promptly hosed down the house with gallon after gallon of "anti-bacterial" this and "sanitizing" that, exacerbating the problem. Disinfect the kitchen after slicing up chicken and leave the rest of the house alone. Not only are you selecting the resistant bacteria, your disabling your immune system so when a bug does get in, there is nothing in place to fight it.

Put down the Purell and step back!
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by lindakaycollier May 29, 2008 1:23 PM PDT
I never heard of c diff before my elderly mother was in a nursing facility for physical therapy. She became ill and was in the hospital for several days and received IV antibiotics and just got worse. We finally were told she tested positive for c diff. I began to research it and was amazed that we had never heard anything on the news about this. We are exposing our little children and everyone else when we go to health facilities and are unaware of such a contagious disease. Also, we are not told that many other countries are treating c diff with fecal flora therapy. Especially in Canada and Austrailian. Just put "fecal flora therapy" in your search box and you can find out about this. My mother''s infectious disease doctor mentioned it to us, but they won''t do the procedure in our hospitals or even tell you about it. This fecal flora therapy is stopping the c diff in many, many cases. It may sound gross but when it works and saves lives and money, it''s worth it. Check it out and tell others about it. It should be on the CBS News and other broadcast networks and cable.
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by lindakaycollier May 29, 2008 1:28 PM PDT
If you are interested in other means of treating c diff, just put fecal flora therapy in your search box and you will learn much about this method of treatment used in Canada and other countries.
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by rf35 May 29, 2008 1:30 PM PDT
"...it works and saves lives and money,"

Which is why it isn''t used in American medicine. If it doesn''t cost a fortune, nobody is interested.
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by downsteamjim May 29, 2008 4:32 PM PDT
Since 2000 is has become a problem. 5,500 killed in one year. Must be Bush''s fault.
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by maba7 May 29, 2008 4:38 PM PDT
Beef cattle, chickens and hogs are given anti-biotics to increase weight gain and prevent illness that might interfere with maximum profits.
My ex-husband had major surgery (which was considered a total success) involving circulation in the lower legs, he developed MRSA in the hospital and C diff in the convalescent facility. Back to hospital because of dehydration. Every time he improved slightly, he was sent back to the convalescent facility. Surgery was done in March 2005, he died in June 2005 from the institution-borne infections. Neither the hospital or nursing home seemed to have heard of probiotics.
Unfortunately, both of the infections are moving away from the institutions and into the general population.
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by geolough May 29, 2008 9:56 PM PDT
I am a pharmacist. I have NEVER heard of anyone getting C.diff by simply taking antibiotics-this idea is way off base. My father died from C.diff at the age of 56 in 2006. The ONLY patients I have seen with C.diff have acquired it in a hospital/care facility. Yes, these patients often have weakened immune systems, and/or other underlying conditions. However, many patients develop C.diff without taking a single dose of an antibiotic. So where is it coming from??? From uninformed, hurried, careless medical and hospital staff. My father had consults with SEVEN different specialities of physicians, a total of TWELVE different doctors, four physicians assistants, and countless nurses visit his room-all in his last 2 days of life. There were 3...yes...THREE medical people who WASHED THEIR HANDS before and after examing my dad-and he had a sink directly next to his bed. All used alcohol gel at the entrance of his door-but this is not effective vs. C.diff.. Hand washing is vital. Also, look at one other major factor as a cause, most infected individuals are on a PPI, or H2 inhibitor, these drugs decrease the amount of stomach acid-a vital defense in killing the spores. If your loved one is sharing a room with a C.diff patient, GET THEM OUT, no matter the cost. This is a horrible way to die and a horrible way to witness someone you love to die-there is no dignity in this illness, and it is so easy to prevent if everyone is educated.
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by h5mind June 1, 2008 7:42 AM PDT
The human immune system is offered refered to as a "black box" since so little is known about it. Medical professionals can certainly list a plethora of factors relating to poor immune system function, but rarely if ever know how to cure any of the resulting diseases. This, I suspect, is why they prefer to focus on expensive (and lucrative) long term treatment instead of cure. If ''modern'' medicine has failed you, try the following: 1)Eat organic, unprocessed foods, epecially fruits, vegetables, meats and milk, 2)Avoid using flouridated toothpaste, water and beverages containing it, 3)Avoid high fructose corn syrup, 4)Eat raw honey each day, especially if you suffer from allergies (which are themselves evidence of auto-immune disorder),5) and finally, do not take vaccinations if they contain mercury, aluminum or formaldehyde. Better yet, refuse all of them. Groups such as the Amish follow these rules and do not suffer from the many mystery illnesses so rampant today. Their population is almost entirely devoid of cancer as well. As Aristole said, "food is the first medicine".
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