The Mixed Blessing Of Genetic Testing

(CBS)  Gretchen Robertson felt like a ticking time bomb.

Her father had colon cancer, and her grandmother died from it -- at just 45. So Gretchen got screened at 38 - and it's a good thing she did.

"What did your first colonoscopy find?' CBS News anchor Katie Couric asked her.

"I had a 17-millimeter polyp that was cancerous," Gretchen said. "Thirty-eight just seemed so young."

But despite the family history, Gretchen couldn't get a colonoscopy on her brother John's "to-do" list.

"Every time she asked me, I said 'yea yea, I'll get around to it one of these days,'" John said. "Anything you don't want to do is easy to put off."

But there was a new sense of urgency when Gretchen tested positive for a specific type of colon cancer that's hereditary. It's called Lynch Syndrome.

"Having the gene, you're more at risk, more quickly," Gretchen said.

Lynch Syndrome is caused by a genetic defect. If you have it, your chances of getting colon cancer go up -- to almost 80 percent. Lynch Syndrome also causes the cancer to strike earlier - lowering the average age for diagnosis from 65 down to 45.

It's just one of some 1,300 diseases and disorders that can now be predicted with genetic testing. And for families like Gretchen's, this brave new world is a mixed blessing.

"Some of us have this curiosity to know everything we possibly can. And other people are not so interested in information that might have negative consequences," Dr. Francis Collins said.

And there are other concerns associated with genetic testing. Gretchen and John have two other siblings who declined to be part of this interview, fearing their insurance companies would hold their DNA against them. But Gretchen thinks this critical information is cost-effective.

"If you get a genetic test that shows you're at risk for things, you can prevent the cancer. And I think, what more could you ask for? The insurance won't get the bills for cancer treatment, because the cancer won't develop," Gretchen said.

One month ago, John gave in and decided to be tested for the gene. A simple blood test determines if he's a carrier.

"It's not nerve racking, because now there's a sense of relief that I might not have the gene. Whereas, I felt I always did have the gene," John said after getting the blood test.

Last week, John's results came in. They showed that he does have the gene.

Though it's not guaranteed he'll get colon cancer, John knows his odds just increased significantly.

"Genetic testing clarifies risk. And knowing your risk allows you to take steps that could save your life," said counselor Anna Leininger.

The good news is colon cancer is 90 percent curable, if found early. So john should now have a colonoscopy every year. His three children will need annual screenings too, starting in their twenties - unless a genetic test proves they're negative.

Luckily, Gretchen's colon cancer was treatable - but she's not taking any chances. Yesterday, knowing that Lynch Syndrome puts her at risk for other kinds of cancers, like endometrial and ovarian, she had a complete hysterectomy.

"In some ways, do you feel as if you've opened up Pandora's box? Do you ever say 'what next?'?" Couric asked her.

"Yes, I feel like, 'oh boy, this is really a lot.' There are days it's very hard," Gretchen said. "But I look at my three kids, and I think, 'wouldn't have grandmother have given anything to have this opportunity, to be screened for all these things once a year instead of the alternative?' So that kind of keeps me going."

Meanwhile, in Washington, there's a bill awaiting President Bush's signature that would prohibit discrimination based on your genetic information. It would allow you to have genetic testing without fear of losing your job or your health insurance.

[sabrinaport]

This is correct. I have just recently discovered my years of CRPS syndrome was due to an undiagnosed congenital deficiancy. My children are sick, my entire family is sick. I have 20 years of my medical history, at my fingertips as well as my children. It is unbelievable how they could have missed this so long. My son has his first "inherited adrenal attack" at just 12 months old and he is now 15 and I am just finding out. We have to push this testing. My family has been sick for years and I am sure there are a lot of others. I don''t know how many people have their journeys completely documented. By the time you get a diagnosis or are dead, you have seen too many doctors, all over the place and an accurate history is almost impossible. Not this time. I have years of proof. I was sick from the start.

[mrsjauregui]

CLEARLY "ejcspau" OR this persons family, has not been diagnosed with a genetc disease or disorder. We know that we "can''t play God" BUT He has given us the gift of faith-filled scientist and doctors who can and do help us every single day.

When your genetic disposition brings death to you and generations to follow, YOU must be resposible, find a genetic counselor, get the predictive genetic testing.

Unfortunately, my familys "Mixed Blessing" is not treatable! My grandmother was diagnosed with Huntington''s Disease in 1993 afer years of misdiagnoses after misdiagnoses. My fathers younger brother was diagnosed with Huntington''s soon after. My grandmother died in 1999 from this consuming disease. My father was later diadnosed with HD, as well as my self. My uncle died last week! I fear for my own children''s fates!

So rather than sounding idiotic, maybe "ejcspau" and other who are like minded can simply offer up a prayer for those of who are trying not to fall apart on a day to day basis. God gives my children and I great strength every day. We know "He''ll take us when He is ready, no matter how many doctors tell us otherwise".

[darnedsocks]

A FEDERAL LAW NEEDS TO BE PASSED THAT INSURANCE COMPANIES CANNOT DENY YOU COVERAGE BASED ON A TEST LIKE THIS. ANOTHER LAW SHOULD BE PASSED THAT ONCE DIAGNOSED WITH A DISEASE, THE NO INSURANCE COMPANY CAN DISCRIMINATE AGAINST THAT PERSON OR DENY THEM COVERAGE. THE PLANS ARE A ROUND-ROBIN AKA A "POOL OF MONEY" THAT SHOULD COVER THE ILL, WHILE THE HEALTHY CONTINUE TO PAY...IN THIS WAY, IT COVERS US ALL....OUR LEGISLATORS NEED TO WRITE AND PASS THIS LAW AT THE FEDERAL LEVEL. IT IS THE MOST SIMPLE SOLUTION TOWARDS UNIVERSAL HEALTH CARE.

[ejcspau]

You can''t play God. He''ll take you when He is ready, no matter how many doctors tell you otherwise. Poor woman, letting doctors control her life.