August 21, 2007 2:00 PM
- Text
Study: Cranberries Boost Cancer Drug
- Adele's Grammy Comeback After Vocal Cord Surgery
- Treating Sleep Apnea in Kids Improves Behavior, Quality of Life
- Chemo May Not Harm Unborn Baby
- C-Sections Not Always Best for Small Babies
- CDC: Doctors Increasingly Prescribe Exercise
- Osteoporosis Medication Linked to Unusual Thigh Fractures
- More from WebMD »
Cranberries, cranberry, fruit (CBS/iStockphoto)
(WebMD)
A simple cranberry juice extract makes platinum-based cancer drugs six times more potent against ovarian cancer.
The test-tube findings are a long way from cancer patients' bedsides. But Rutgers University natural products researchers Ajay P. Singh, PhD, and Nicholi Vorsa, PhD, are optimistic.
"This has opened up exciting possibilities for therapeutic intervention associated with platinum therapy," Singh and Vorsa say in a news release.
Platinum-based chemotherapy is the mainstay of treatment for ovarian cancer. But over time, the cancers tend to become resistant to the drugs. This means increased chemotherapy dosage—and increased toxicity to patients.
The researchers note that compounds isolated from cranberries kill human ovary, brain, and prostate cells in laboratory studies. This anticancer activity seems to come from a family of chemicals called proanthocyanidin(PACs).
These "amazing chemical entities," Singh and Vorsa suggest, are unique to cranberries and are not found in other fruits.
Exactly how the cranberry compounds work isn't known. But in their lab studies, Singh and Vorsa tested them against platinum-resistant ovarian cancer cells.
Singh and Vorsa found that in the presence of cranberry extract—which came from a commercially available, 27 percent juice cranberry drink— platinum-based chemotherapy was six times more effective against platinum resistant ovarian cancer cells.
They will soon begin animal studies to see whether this happens outside the laboratory. For the time being, however, they warn patients not to start drinking significant quantities of cranberry juice without their doctors' permission. Cranberry juice itself, they note, is not a cure for cancer.
Singh and Vorsa reported the findings in a presentation to the 234th
national meeting of the American Chemical Society.
By Daniel DeNoon
Reviewed by Louise Chang
©2007 WebMD, Inc. All rights reserved
The test-tube findings are a long way from cancer patients' bedsides. But Rutgers University natural products researchers Ajay P. Singh, PhD, and Nicholi Vorsa, PhD, are optimistic.
"This has opened up exciting possibilities for therapeutic intervention associated with platinum therapy," Singh and Vorsa say in a news release.
Platinum-based chemotherapy is the mainstay of treatment for ovarian cancer. But over time, the cancers tend to become resistant to the drugs. This means increased chemotherapy dosage—and increased toxicity to patients.
The researchers note that compounds isolated from cranberries kill human ovary, brain, and prostate cells in laboratory studies. This anticancer activity seems to come from a family of chemicals called proanthocyanidin(PACs).
These "amazing chemical entities," Singh and Vorsa suggest, are unique to cranberries and are not found in other fruits.
Exactly how the cranberry compounds work isn't known. But in their lab studies, Singh and Vorsa tested them against platinum-resistant ovarian cancer cells.
Singh and Vorsa found that in the presence of cranberry extract—which came from a commercially available, 27 percent juice cranberry drink— platinum-based chemotherapy was six times more effective against platinum resistant ovarian cancer cells.
They will soon begin animal studies to see whether this happens outside the laboratory. For the time being, however, they warn patients not to start drinking significant quantities of cranberry juice without their doctors' permission. Cranberry juice itself, they note, is not a cure for cancer.
Singh and Vorsa reported the findings in a presentation to the 234th
national meeting of the American Chemical Society.
By Daniel DeNoon
Reviewed by Louise Chang
©2007 WebMD, Inc. All rights reserved
Popular Now in Health
- Cancer drug reverses Alzheimer's in mice: Study
- Norovirus outbreak hits Rider University in N.J
- Marijuana-smoking motorists twice as likely to crash
- Electric shocks to brain may boost memory: Study
- America's pets also have an obesity epidemic
- Measles patient at Super Bowl prompts health alert
- America's sodium problem: Not from salty snacks?
- Chinese mom gives birth to 15-pound baby
- Caffeine inhalers - the next club drug?
- Skin cancer self-exam: What to look for (PHOTOS)
- 4.5 million Americans over 50 have artificial knees
- Things You Didn't Know About Your Penis
- PICTURES: 15 Shocking Sexual Fetishes
- Let's Move! campaign turns 2 today: Is it working?
- Drinking soda raises risk for asthma, COPD: Study
- Christina Hendricks: Too Big for Hollywood?
- Woman spotlights uterus didelphys on talk show
Latest CBS News Headlines
on Facebook
on CBS News
- McCartney to debut new songs live on iTunes stream
- Capello: No plans to coach in Italy
- Redknapp flattered by England coach consideration
- FA chiefs meet to consider Capello's successor
on Facebook
- Adele sings a cappella for Anderson Cooper
- Beyonce and Jay-Z post first photos of Blue Ivy Carter
- Timothy Dolan: Birth control tweak a "first step"
on CBS News






