Promising Tests For Alzheimer's Patients

Drug To "Feed" Brain Cells Among Experimental Drugs For Alzheimer's Set For Large-Scale Testing

(CBS/AP)  Drinking a milkshake-style medicine at breakfast seems to feed brain cells starved from Alzheimer's damage, researchers reported Monday. It is one of four promising experimental drugs poised for large-scale testing against the brain-destroying disease.

The milkshake drug, called Ketasyn, is a dramatically different way to approach dementia. It hinges on recent research suggesting diabetic-like changes in brain cells' ability to use sugar for energy play a role in at least some forms of Alzheimer's.

Special fatty acids in Ketasyn offer an alternate food source to rev up those hungry neurons, researchers told an international Alzheimer's meeting here Monday. In a study of 150 patients, adding Ketasyn to their regular medicines produced a small but important boost in mental functioning, but only in people who don't carry an Alzheimer's gene called ApoE4. Still, that is about half of all patients.

"We see this as a co-therapy," not a way to stop Alzheimer's, cautioned Dr. Lauren Constantini, a former Harvard scientist now with the company Accera Inc. that is developing the drug.

For the first time, reports CBS News medical correspondent Dr. Jon LaPook, scientists are targeting what they believe may be a root cause of Alzheimer's: brain damage from clumps of a protein called beta amyloid.

New drugs are testing three approaches: enzyme blockers to stop the amyloid from forming; a drug called Alzhemed to stop the amyloid from clumping; and vaccines to help the immune system clean up the amyloid, adds LaPook.

Monday brought frustrating news on that front: The first of those amyloid blockers to make it to large-scale, Phase III testing has hit a hurdle, and scientists will have to wait until at least month's end to learn if Alzhemed really works.

The problem is statistical, said lead researcher Dr. Paul Aisen of Georgetown University: Hospital-to-hospital differences in other medication use among the study's 1,000 participants prevent an immediate clear comparison of Alzhemed's role. Working with the Food and Drug Administration, researchers are adjusting for those variations, Aisen told the Alzheimer's Association's dementia prevention meeting.

Stay tuned, he said: There are some hints that Alzhemed-treated patients fared better.

Other drugs highlighted Monday:

Eli Lilly & Co. hopes to halt beta-amyloid formation by blocking an enzyme called gamma secretase involved in its creation. Among 51 patients given the still-unnamed drug, those who took the highest dose had a 65 percent reduction of beta-amyloid in their blood. The study did not last long enough to tell if their symptoms improved, too, but the drop was so big that Lilly will begin a Phase III trial early next year to try prove the approach.

"This is a robust effect," said Lilly researcher Dr. Eric Siemers. "How could you not do a Phase III study?"

Also next year, scientists will begin a U.S. study of an old Russian antihistamine against Alzheimer's. A study of 180 Russian patients found the drug Dimebon improved mental functioning, patients' ability to care for themselves and some other measures, said Dr. Rachelle Doody of the Baylor College of Medicine. After a year of treatment, patients' mental functioning hadn't gotten any worse than when they started. Scientists think Dimebon may have some capacity to save neurons from death, said Dr. David Hung, chief executive of manufacturer Medication Inc.

The milkshake drug Ketasyn follows the principle that when someone fasts, the body lives off stored fat. Ketasyn contains fatty acids that the liver metabolizes into substances called ketones, similar to what's produced during a fast. Brain cells can use ketones in place of sugar for energy. That's also similar to the high-fat, low-protein ketogenic diet sometimes used for children with severe epilepsy. Manufacturer Accera is currently hunting funding for a Phase III study, and exploring different formulations for epilepsy and other brain disorders.

Finally, Elan Corp. plans a Phase III trial later this year that will infuse patients with immune-system cells called antibodies to attack the plaque clogging their brains. Elan earlier tried using a vaccine to spark patients' bodies to make their own antibodies; research halted when a handful of participants suffered serious brain inflammation. But Monday, Elan presented evidence backing the general approach: 4 1/2 years after the ill-fated vaccine study, 17 patients still harbor those antibodies, and their Alzheimer's has worsened much slower than their unvaccinated counterparts.


© MMVII, CBS Interactive Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.

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Add a Comment

by jetlizhan June 12, 2007 1:06 PM EDT

'cuse me - i meant magnanana

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by jetlizhan June 12, 2007 1:00 PM EDT

God bless you mannanana - i totally understand. my best friend which is my sister lives in florida - my niece in colorado just had her first baby and i'm unable to visit like i use to. my mom has a nervous fit if i'm not 'in place' at all times. the future is alway a question mark. i just take one day at a time and help with the expense for my loved ones to come visit me in my state.

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by magnanana June 12, 2007 12:46 PM EDT

My mother-in-law was diagnosed with Alzheimer's Disease several years ago. This devastating disease has greatly impacted our family. She no longer recognizes her husband of 62 years and constantly wants her "husband" to come and get her and take her home. (They have lived in their home for the last 40 years.) It's painful to see the anguish and bewilderment in her face. My father-in-law is exhausted from the 24/7 attention required of him. As managers of their medication and meal providers, my husband and I are unable to get away for any more than a few hours. I pray for the day that research yields results that will make this disease more treatable.

Reply to this comment

by jetlizhan June 12, 2007 11:29 AM EDT

my mom has dementia and it's so sad to watch the progression. it not only curtails her life, but mine also. i think it's horrible for the one that has it, but it's so sad for the caregiver/family. it's such an overwhelming feeling of helplessness i was hoping never to experience.

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[jetlizhan]

'cuse me - i meant magnanana

[jetlizhan]

God bless you mannanana - i totally understand. my best friend which is my sister lives in florida - my niece in colorado just had her first baby and i'm unable to visit like i use to. my mom has a nervous fit if i'm not 'in place' at all times. the future is alway a question mark. i just take one day at a time and help with the expense for my loved ones to come visit me in my state.

[magnanana]

My mother-in-law was diagnosed with Alzheimer's Disease several years ago. This devastating disease has greatly impacted our family. She no longer recognizes her husband of 62 years and constantly wants her "husband" to come and get her and take her home. (They have lived in their home for the last 40 years.) It's painful to see the anguish and bewilderment in her face. My father-in-law is exhausted from the 24/7 attention required of him. As managers of their medication and meal providers, my husband and I are unable to get away for any more than a few hours. I pray for the day that research yields results that will make this disease more treatable.

[jetlizhan]

my mom has dementia and it's so sad to watch the progression. it not only curtails her life, but mine also. i think it's horrible for the one that has it, but it's so sad for the caregiver/family. it's such an overwhelming feeling of helplessness i was hoping never to experience.