Disease May Be Behind Hatfield-McCoy Feud

Von Hippel-Lindau Produces "Fight Or Flight" Hormones, Hair-Trigger Rage And Outbursts

(CBS/AP)  The most infamous feud in American folklore, the long-running battle between the Hatfields and McCoys, may be partly explained by a rare, inherited disease that can lead to hair-trigger rage and violent outbursts.

Dozens of McCoy descendants apparently have the disease, which causes high blood pressure, racing hearts, severe headaches and too much adrenaline and other "fight or flight" stress hormones.

The Hatfields and McCoys have a storied and deadly history dating to Civil War times in the 1860s. Their generations of fighting over land, timber rights and even a pig are the subject of dozens of books, songs and countless jokes. Unfortunately for rural Appalachia, the mountain area stretching from southern New York state to northern Mississippi, the feud is one of its greatest sources of fame.

The spat officially ended with the formal truce declaration along the Kentucky-West Virginia border in 2003, reports CBS News correspondent Jim Krasula.

No one blames the whole feud on the disease, but doctors say it could help explain some of the clan's notorious behavior.

"This condition can certainly make anybody short-tempered, and if they are prone because of their personality, it can add fuel to the fire," said Dr. Revi Mathew, a Vanderbilt University endocrinologist treating one of the family members.

Von Hippel-Lindau disease, which afflicts many family members, can cause tumors in the eyes, ears, pancreas, kidney, brain and spine. Roughly three-fourths of the affected McCoys have pheochromocytomas — tumors of the adrenal gland.

The small, bubbly-looking orange adrenal gland sits atop each kidney and makes adrenaline and substances called catecholamines. Too much can cause high blood pressure, pounding headaches, heart palpitations, facial flushing, nausea and vomiting. There is no cure for the disease, but removing the tumors before they turn cancerous can improve survival.

Several genetic experts have known about the disease plaguing some of the McCoys for decades, but kept it secret. The Associated Press learned of it after several family members revealed their history to Vanderbilt University doctors, who are trying to find more McCoy relatives to warn them of the risk.

One doctor who had researched the family for decades called them the "McC kindred" in a 1998 medical journal article tracing the disease through four generations.

"He said something about us never being able to get insurance" if the full family name was used, said Rita Reynolds, a Bristol, Tenn., woman with the disease. She says she is a McCoy descendant and has documents from the doctor showing his work on her family.

She is speaking up now so distant relatives might realize their risk and get help before the condition proves fatal, as it did to many of her ancestors.

Back then, "we didn't even know this existed," she said. "They just up and died."

[nrgspirit]

I haven't read all the posts, so I'm sure this joke has been done, but...


Maybe this theory explains the current Bushit administration.

[che345]

lol im kidding i am eal intersted in this lol ha ha

[che345]

this stories are feaking false we do not get the fraeaking pissed off at everthing you *** thats right get your stories right you fraking idiots *** it .... lol

[shoewasha]

my mother-in-law must be kin to the Hatfields

[bbrundj]

Does this include ridiculous commenting individuals who seem to be down on everything? Those who forget the past, are condemned to condemn history, I guess.

[pakaal]

Dammit, this sort of story really pisses me off!!!!!!

-L. McCoy

[taylpatr]

Maybe we need to check Cheney to see if he's got a bad gland. Maybe that's why he's such an a**hole.

[last121868]

didinhale:
You are correct in your first statement.
What was your point with your second????

[galaxiana]

Wow, when you see 6 out of the top 10 stories that should be in the "strange news" category as the top U.S. headlines, it must REALLY be a slow news day!

Besides belonging in the "strange news" category, doesn't the Hatfield/McCoy fued also qualify for the OLD NEWS category?

CBS must have sent most of its staff home for the weekend Thursday afternoon instead of Friday afternoon.

Ah, wait, that's right, they're probably all away celebrating Passover (which started Tuesday.) ;)

[extremophil]

I heard that diarrhea runs in the jeans, too.