Jodie Meeks added 10 of his 15 points in a 14-2 third-quarter run that broke the game open and led to the ejection of Nets coach Avery Johnson for arguing a non-call after point guard Devin Harris apparently was fouled by Elton Brand.
Andre Iguodala added 16 points and Brand had 15 and 10 rebounds for the 76ers, who won their fifth in six games and beat the Nets for the third time in as many meetings this season.
Harris, Brook Lopez and Kris Humphries all had 16 points for New Jersey, which lost for only the second time in its last seven home games.
Leading by nine at the half, Philadelphia took command early in the third quarter when Meeks and center Spencer Hawes scored all the points in the big run that turned a seven-point game into a 69-48 laugher.
Meeks started the run with a three-point play and a 3-pointer, and Hawes hit an alley-oop on a pass from Holiday for a 61-46 lead.
After Travis Outlaw scored inside for New Jersey, there were couple of possessions before Johnson got tossed for the first time as the Nets coach.
Harris was trying to dribble near the foul line and was stopped cold by Brand, who seemed to paw him with both hands to the chest.
Replays showed Brand never touched the ball and seconds later Harris was stripped of the ball. Players on both teams stood and waited for a call.
When none was made, Meeks went the other way for a layup.
Johnson simply lost it and went after official Brent Barnaky and got two quick technical fouls and was ejected.
Johnson walked off the court to chants of "Avery, Avery, Avery" and former Raptors coach and Nets assistant Sam Mitchell ran the team for the rest of the game.
New Jersey was able to cut the lead to single digits a couple of times the rest of the way, but Philadelphia always seemed to make a big play, getting a three-point play and a 3-point field goal from Williams late in the third quarter and a three-point play by Evan Turner also late in the third.
Notes: The Sixers have won two in a row on the road, pushing their road record to 7-18. ... Philadelphia had 35 fastbreak points, compared to 8 for New Jersey. ... The Sixers were a perfect 18 of 18 from the free throw line. ... Nets rookie Derrick Favors had 11 rebounds. ... Hawes had a game-high 12 boards.