Study: Father's age a likely factor in autism

(CBS News) The cause of autism is one of the great mysteries of medicine, but we found out something new and important Wednesday.

A report in the medical journal "Nature" says it is the age of the father at the time of conception, not the age of the mother that can raise the risk of autism in a child.

With more men becoming fathers later in life, it could help explain the rise in autism.

The study's senior author - a scientist in Iceland - writes: "Conventional wisdom has been to blame the developmental disorders of children on the age of mothers"... but "it is the age of fathers that appears to be the real culprit."

Dr. Dolores Maldespina, a psychiatrist at NYU Langone Medical Center, said she finds the research eye opening.

"This study shows that new mutations are frequent enough as men age that fathers aging alone can explain the increase for the risk of autism," Maldespina said.

The study says a father's age could account for 15 to 30 percent of cases of autism, and perhaps other disorders like schizophrenia as well.


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"This study shows that when these diseases present without a family history, the origin is in the sperm of the man and that the risk goes up as the man ages," Maldespina said.

The latest numbers from the Centers for Disease Control indicate the rate of autism has doubled in the last six years from 1 in 162, to 1 in 88.

The number of men 40 and older who father a child has increased by more than 30 percent since 1980. The study is the first to quantify the consequence of a father's age: For every 1-year of age, two genetic mutations were discovered in offspring that could be traced to the father, and up to 65 mutations in the offspring of 40-year-old men. The average number of mutations traced to the mother was 15, no matter what her age.

But Yale researcher Dr. Stephan Sanders warns it's too soon to definitively say the father's age is the top factor.

"So I think it is fair to say increasing father's age does increase the instance of autism but that effect is small," Sanders said.

Accompanying the study in the journal "Nature" was an editorial suggesting that if the findings hold up, that young men collecting and storing their sperm for later use could be what they call "a wise individual decision."

  • Jim Axelrod

    Jim Axelrod is the anchor of the Saturday edition of the "CBS Evening News" and a national correspondent for CBS News, reporting for the "CBS Evening News with Scott Pelley" and other CBS News broadcasts.

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