DAMASCUS, Syria - An explosion ripped through a busy intersection in the Syrian capital Friday, hitting a bus carrying police and killing up to 25 people in what Syrian authorities said was the second suicide attack in as many weeks.
The bus was left riddled with shrapnel, blood splattered on its seats and pooled on the asphalt of the street after the blast, which came exactly two weeks after twin bombings targeting intelligence agencies in the capital killed 44 people. The bombings mark a dramatic escalation of bloodshed as Arab League observers tour the country to investigate President Bashar Assad's bloody crackdown on a 10-month-old popular revolt.
Interior Minister Mohammed Shaar said a suicide bomber "detonated himself with the aim of killing the largest number of people."
CBS News' George Baghdadi reported from the scene that the state-owned bus was totally destroyed, and a number of cars in the vicinity also were heavily damaged and splattered with blood.
Baghdadi says the attack hit in the heart of Damascus, only about 10 yards from the local police station.
Syrian television showed residents and paramedics carrying human remains, holding them up for the camera.
The explosion damaged the nearby police station, shattering its glass, and left blood and flesh in the streets, according to an Associated Press reporter at the scene. Police cordoned off the area with yellow police tape.
Syria's state media, SANA, said the initial death toll is 25 people. The figure includes 10 people confirmed dead and the remains of an estimated 15 others, whose bodies had yet to be identified. SANA said many of the dead are civilians.
In a sign of just how polarized Syria has become, the opposition has questioned the government's allegations that terrorists are behind the attacks suggesting the regime itself could have been behind the violence to try to erode support for the uprising and show the observer team that it is a victim in the country's upheaval.
The government has long contended that the turmoil in Syria this year is not an uprising but the work of terrorists and foreign-backed armed gangs.
Baghdadi reports that in the aftermath of the blast, an anti-Assad demonstration sprang up in the area, but those opposition supporters quickly disappeared as security forces sealed off the area.
Soon after, hundreds of pro-Assad demonstrators descended on the area, carrying banners and signs expressing support for the leader and chanting his name.
Baghdadi says the situation in Damascus has become dramatically more tense in recent weeks, with many residents trying to remain in their homes when possible.
The opposition has produced no evidence backing its accusations, and no one but Syrian authorities have access to investigate the blasts. A spokesman for the Syrian National Council opposition umbrella group called for an independent probe.
"It is a continuation of the regime's dirty game as it tries to divert attention from massive protests," Omar Idilbi said. "We call upon for an independent international committee to investigate these crimes that we believe that the regime planned and carried out."
Also Friday, SANA said terrorists blew up a pipeline that carries diesel from the central province of Homs to nearby Hama. There have been several pipeline blasts in recent months, but it is unclear who is behind them.
The Arab League observers started work Dec. 27 on a mission to monitor Syria's compliance with a League-drafted peace deal. Under the deal, Assad's regime is supposed to pull its military off the streets of cities and stop its crackdown on the protesters calling for the president's ouster.
Despite the observers' presence, violence has spiked, with Syrian activists saying up to 400 people have been killed since Dec. 21. The U.N. says the overall toll since the revolt began is more than 5,000.
Arab League Deputy Secretary-General Ahmed bin Helli condemned the attack, saying that "when there are explosions of this nature, this is a dangerous development."
"This is our fear now, that the situation slips out of control, and that the country heads toward threats to peace or sectarian strife or civil war," he told The Associated Press in Cairo, where the League is based.
On Wednesday, Qatar's prime minister said on Wednesday that the Arab Leagueand he was turning to the United Nations for help.
Friday's blast went off at an intersection in the central Damascus neighborhood of Midan on Friday, the start of the weekend in Syria and much of the Arab world. Midan is one of several Damascus neighborhoods that has seen frequent anti-Assad protests on Fridays since the uprising began in March.
"I heard the explosion at about 11:15 and came running here. I found bodies on the ground including one of a man who was carrying two boxes of yogurt," Midan resident Anis Hassan Tinawi, 55, told The Associated Press.
The bus, which was carrying policemen at the time, appeared to be the target of the bomber, said a Syrian official, speaking on condition of anonymity because he was not allowed to speak publicly to the media.
The official also said that a smaller bomb exploded Friday in the Damascus suburb of Tal, killing a girl. Security experts dismantled another bomb in the same area, he said.
Compared to many parts of the country which have been convulsed by the 10-month old uprising, Damascus has been relatively quiet under the tight control of ruthless security agencies loyal to Assad.
But violence in the capital has been on the rise over the last two months. On Dec. 23, according to the Syrian authorities, two car bombers blew themselves up outside the heavily guarded compounds of the country's intelligence agencies, killing at least 44 people and wounding 166.
If the official account is correct, they would be the first suicide bombings during the uprising. State-run TV said the al Qaeda terrorist network was possibly to blame for previous attack, and blamed "terrorists" for the latest one, without giving specifics.
Adding to the bloodshed in recent months, dissident soldiers who broke from the military to side with peaceful protesters have launched attacks on government sites, raising fears of civil war.
Air force Col. Riad al-Asaad, leader of the main armed group fighting the regime, denied responsibility for Friday's bus bombing in an interview with pan-Arab Al-Jazeera TV.
He said his organization, the Free Syrian Army, "doesn't have the experience to carry out such explosions" and said the regime "is the plotter for this attack." He spoke from Turkey, where the group is based.